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Adequate acclimatization time to enable adjustment to hypoxic conditions is one of the most important aspects for mountaineers ascending to high altitude. Accordingly, most reviews emphasize mechanisms that cope with reduced oxygen supply. Howev[...]texto impreso
Yazicioglu, Tolga ; Mühlfeld, Christian ; Autilio, Chiara ; Huang, Cheng-Kai ; Bär, Christian ; Dittrich-Breiholz, Oliver ; Thum, Thomas ; Pérez Gil, Jesús ; Schmiedl, Andreas ; Brandenberger, Christina | American Physiological Society | 2020-10-14Morbidity and mortality rates in acute lung injury (ALI) increase with age. As alveolar epithelial type II cells (AE2) are crucial for lung function and repair, we hypothesized that aging promotes senescence in AE2 and contributes to the severit[...]texto impreso
Makarov, Valeri A. ; Castellanos, Nazareth P. ; Malmierca, Eduardo ; Núñez, Ángel | American Physiological Society | 2007Precise and reproducible spike timing is one of the alternatives of the sensory stimulus encoding. We test coherence (repeatability) of the response patterns elicited in projecting gracile neurons by tactile stimulation and its modulation provok[...]texto impreso
Villafuerte, Francisco C. ; Macarlupu, Jose Luis ; Anza-Ramirez, Cecilia ; Corrales-Melgar, Daniela ; Vizcardo-Galindo, Gustavo ; Corante, Noemi ; Leon-Velarde, Fabiola | American Physiological Society | 2020-06-10T18:11:31ZExcessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop EE despite having alt[...]texto impreso
Autilio, Chiara ; Shankar-Aguilera, Shivani ; Minucci, Angelo ; Touqui, Lhoussaine ; De Luca, Daniele | American Physiological Society | 2019-02-21Hypothermia can modify surfactant composition and function. Secretory phospholipase A2 (sPLA2) hydrolyses surfactant phospholipids and is important in the pathobiology of several critical respiratory disorders. We hypothesize that sPLA2 activity[...]texto impreso
Gammella, Elena ; Díaz, Victor ; Recalcati, Stefania ; Buratti, Paolo ; Samaja, Michele ; Dey, Soumyadeep ; Noguchi, Constance Tom ; Gassmann, Max ; Cairo, Gaetano | American Physiological Society | 2019-02-06T14:52:12ZUnder conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic c[...]texto impreso
Gammella, Elena ; Díaz, Victor ; Recalcati, Stefania ; Buratti, Paolo ; Samaja, Michele ; Dey, Soumyadeep ; Noguchi, Constance Tom ; Gassmann, Max ; Cairo, Gaetano | American Physiological Society | 2020-06-10T18:11:33ZUnder conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic c[...]texto impreso
Blanco Imperiali, Ayelén M. ; Gómez-Boronat, Miguel ; Madera, Diego ; Valenciano González, Ana Isabel ; Alonso Gómez, Ángel Luis ; Delgado Saavedra, María Jesús | American Physiological Society | 2018-02Nocturnin (NOC) is a unique deadenylase with robust rhythmic expression involved in the regulation of metabolic processes in mammals. Currently, the possible presence of NOC in fish is unknown. This report aimed to identify NOC in a fish model, [...]texto impreso
Makarova J, Makarova VA, Herreras O. Generation of sustained field potentials by gradients of polarization within single neurons: a macroscopic model of spreading depression. J Neurophysiol 103: 2446-2457, 2010. First published March 10, 2010; d[...]texto impreso
Tremblay, Joshua C. ; Coombs, Geoff B. ; Howe, Connor A. ; Vizcardo-Galindo, Gustavo A. ; Figueroa-Mujica, Romulo J. ; Bermudez, Daniela ; Tymko, Michael M. ; Villafuerte, Francisco C. ; Ainslie, Philip N. ; Pyke, Kyra E. | American Physiological Society | 2019-12-06T21:04:46ZExcessive erythrocytosis [EE; hemoglobin concentration (Hb) > /= 21 g/dL in adult men] is a maladaptive high-altitude pathology associated with increased cardiovascular risk and reduced reactive hyperemia flow-mediated dilation (FMD); however,[...]texto impreso
Laouafa, Sofien ; Elliot-Portal, Elizabeth ; Revollo, Susana ; Schneider-Gasser, Edith-M. ; Joseph, Vincent ; Voituron, Nicolas ; Gassmann, Max ; Soliz, Jorge | American Physiological Society | 2019-02-06T14:45:36ZThe impact of cerebral erythropoietin (Epo) in the regulation of the hypercapnic ventilatory response (HcVR) is controversial. While we reported that cerebral Epo does not affect the central chemosensitivity in C57Bl6 mice receiving an intracis[...]texto impreso
Bermudez, Daniela ; Azad, Priti ; Figueroa-Mujíca, Rómulo ; Vizcardo-Galindo, Gustavo ; Corante, Noemi ; Guerra-Giraldez, Cristina ; Haddad, Gabriel G. ; Villafuerte, Francisco C. | American Physiological Society | 2020-07-14T00:00:56ZExcessive erythrocytosis (EE) is the main sign of chronic mountain sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism of EE is still controversial, [...]texto impreso
Bermudez, Daniela ; Azad, Priti ; Figueroa-Mujíca, Rómulo ; Vizcardo-Galindo, Gustavo ; Corante, Noemi ; Guerra-Giraldez, Cristina ; Haddad, Gabriel G. ; Villafuerte, Francisco C. | American Physiological Society | 2019-12-06T20:57:40ZExcessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism of EE is still controversial, [...]texto impreso
Muckenthaler, M.U. ; Mairbäurl, H. ; Gassmann, M. | American Physiological Society | 2020-12-14T16:10:01ZResidents at high altitude cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here, we review available data [...]texto impreso
Makarov, Valeri A. ; Korovaichuk, A. ; Makarova, J. ; Benito, N. ; Herreras, Oscar | American Physiological Society | 2010-07Korovaichuk A, Makarova J, Makarov VA, Benito N, Herreras O. Minor contribution of principal excitatory pathways to hippocampal LFPs in the anesthetized rat: A combined independent component and current source density study. J Neurophysiol 104: [...]
