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Moreno, Marta ; Tong-Rios, Carlos ; Orjuela-Sanchez, Pamela ; Carrasco-Escobar, Gabriel ; Campo, Brice ; Gamboa, Dionicia ; Winzeler, Elizabeth A. ; Vinetz, Joseph M. | American Chemical Society | 2018-11-30T02:09:31ZIn vitro culture of Plasmodium vivax liver stages underlies key understandings of the fundamental biology of this parasite, particularly the latent, hyponozoite stage, toward drug and vaccine development. Here, we report systematic production of[...]texto impreso
Orjuela-Sanchez, Pamela ; Villa, Zaira Hellen ; Moreno, Marta ; Tong-Rios, Carlos ; Meister, Stephan ; LaMonte, Gregory M. ; Campo, Brice ; Vinetz, Joseph M. ; Winzeler, Elizabeth A. | American Chemical Society | 2018-11-30T03:10:44ZTo develop new drugs and vaccines for malaria elimination, it will be necessary to discover biological interventions, including small molecules that act against Plasmodium vivax exoerythrocytic forms. However, a robust in vitro culture system fo[...]texto impreso
LaMonte, Gregory M. ; Orjuela-Sanchez, Pamela ; Calla, Jaeson ; Wang, Lawrence T. ; Li, Shangzhong ; Swann, Justine ; Cowell, Annie N. ; Zou, Bing Yu ; Abdel-Haleem Mohamed, Alyaa M. ; Villa Galarce, Zaira Hellen ; Moreno, Marta ; Tong Rios, Carlos ; Vinetz, Joseph M. ; Lewis, Nathan ; Winzeler, Elizabeth A. | Nature Research | 2019-07-04T16:59:30ZThe exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin[...]texto impreso
Koepfli, Cristian ; Rodrigues, Priscila T. ; Antao, Tiago ; Orjuela-Sanchez, Pamela ; Van den Eede, Peter ; Gamboa, Dionicia ; van Hong, Nguyen ; Bendezu, Jorge ; Erhart, Annette ; Barnadas, Celine ; Ratsimbasoa, Arsene ; Menard, Didier ; Severini, Carlo ; Menegon, Michela ; Nour, Bakri Y. M. ; Karunaweera, Nadira ; Mueller, Ivo ; Ferreira, Marcelo U. ; Felger, Ingrid | Public Library of Science | 2019-02-06T14:53:10ZPlasmodium vivax is the geographically most widespread human malaria parasite. To analyze patterns of microsatellite diversity and population structure across countries of different transmission intensity, genotyping data from 11 microsatellite [...]
