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Brito, Julio ; Siques, Patricia ; Arribas, Silvia M. ; Lopez de Pablo, Angel L. ; Gonzalez, M. Carmen ; Naveas, Nelson ; Arriaza, Karem ; Flores, Karen ; Leon-Velarde, Fabiola ; Pulido, Ruth ; Ordenes, Stefany ; Lopez, M. Rosario | Hindawi Publishing Corporation | 2019-02-06T14:52:14ZLong-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and[...]texto impreso
Siques, Patricia ; Brito, Julio ; Schwedhelm, Edzard ; Pena, Eduardo ; Leon-Velarde, Fabiola ; De La Cruz, Juan Jose ; Boeger, Rainer H. ; Hannemann, Juliane | Frontiers Media | 2019-07-04T16:59:21ZBackground: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric hypoxia (CIH) occurs in individuals who commute between sea level and high altitude.[...]texto impreso
Lueneburg, Nicole ; Siques, Patricia ; Brito, Julio ; Arriaza, Karem ; Pena, Eduardo ; Klose, Hans ; Leon-Velarde, Fabiola ; Boeger, Rainer H. | Hindawi Publishing Corporation | 2019-02-22T14:54:33ZChronic intermittent hypoxia (CIH) and chronic hypoxia (CH) are associated with high-altitude pulmonary hypertension (HAPH). Asymmetric dimethylarginine (ADMA), a NO synthase (NOS) inhibitor, may contribute to HAPH. This study assessed changes i[...]texto impreso
Siques, Patricia ; Brito, Julio ; Flores, Karen ; Ordenes, Stefany ; Arriaza, Karem ; Pena, Eduardo ; Leon-Velarde, Fabiola ; Lopez de Pablo, Angel L. ; Gonzalez, M. C. ; Arribas, Silvia | Frontiers Media | 2018-12-01T00:04:14ZBackground: In chronic hypoxia (CH) and short-term chronic intermittent hypoxia (CIH) exposure, glycemia and insulin levels decrease and insulin sensitivity increases, which can be explained by changes in glucose transport at skeletal muscles in[...]texto impreso
Lüneburg, Nicole ; Siques, Patricia ; Brito, Julio ; De La Cruz, Juan Jose ; Leon-Velarde, Fabiola ; Hannemann, Juliane ; Ibanez, Cristian ; Boger, Rainer H. | Mary Ann Liebert | 2019-01-25T15:28:05ZHypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway. We measured[...]texto impreso
Brito, Julio ; Siques, Patricia ; Lopez, Rosario ; Romero, Raúl ; Leon-Velarde, Fabiola ; Flores, Karen ; Lueneburg, Nicole ; Hannemann, Juliane ; Boeger, Rainer H. | Frontiers Media | 2018-12-01T00:04:14ZBackground: Living at high altitude or with chronic hypoxia implies functional and morphological changes in the right ventricle and pulmonary vasculature with a 10% prevalence of high-altitude pulmonary hypertension (HAPH). The implications of w[...]texto impreso
Siques, Patricia ; Lopez de Pablo, Angel Luis ; Brito, Julio ; Arribas, Silvia M. ; Flores, Karen ; Arriaza, Karem ; Naveas, Nelson ; Gonzalez, M. Carmen ; Hoorntje, Alexander ; Leon-Velarde, Fabiola ; Lopez, M. Rosario | Hindawi Publishing Corporation | 2020-06-10T18:11:33ZWork at high altitude in shifts exposes humans to a new form of chronic intermittent hypoxia, with still unknown health consequences. We have established a rat model resembling this situation, which develops a milder form of right ventricular hy[...]
