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Brito, Julio ; Siques, Patricia ; Arribas, Silvia M. ; Lopez de Pablo, Angel L. ; Gonzalez, M. Carmen ; Naveas, Nelson ; Arriaza, Karem ; Flores, Karen ; Leon-Velarde, Fabiola ; Pulido, Ruth ; Ordenes, Stefany ; Lopez, M. Rosario | Hindawi Publishing Corporation | 2019-02-06T14:52:14ZLong-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and[...]texto impreso
Brutsaert, Tom D. ; Kiyamu, Melisa ; Elias Revollendo, Gianpietro ; Isherwood, Jenna L. ; Lee, Frank S. ; Rivera-Ch, Maria ; Leon-Velarde, Fabiola ; Ghosh, Sudipta ; Bigham, Abigail W. | National Academy of Sciences | 2019-12-06T21:02:54ZHighland native Andeans have resided at altitude for millennia. They display high aerobic capacity (VO2max) at altitude, which may be a reflection of genetic adaptation to hypoxia. Previous genomewide (GW) scans for natural selection have nomin[...]texto impreso
Siques, Patricia ; Brito, Julio ; Schwedhelm, Edzard ; Pena, Eduardo ; Leon-Velarde, Fabiola ; De La Cruz, Juan Jose ; Boeger, Rainer H. ; Hannemann, Juliane | Frontiers Media | 2019-07-04T16:59:21ZBackground: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric hypoxia (CIH) occurs in individuals who commute between sea level and high altitude.[...]texto impreso
Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Diez-Canseco, Francisco ; Malaga, German ; Cárdenas, María K. ; Carrillo-Larco, Rodrigo M. ; Pesantes, M. Amalia ; Araya, Ricardo ; Boggio, Oscar ; Checkley, William ; García, Patricia J. ; Leon-Velarde, Fabiola ; Lescano, Andres G. ; Montori, Victor ; Pan, William ; Rivera-Chira, Maria ; Sacksteder, Katherine ; Smeeth, Liam ; Garcia, Hector H. ; Gilman, Robert H. | Elsevier | 2019-02-06T14:59:06ZThe CRONICAS Centre of Excellence in Chronic Diseases, based at Universidad Peruana Cayetano Heredia, was created in 2009 with support from the U.S. National Heart, Lung, and Blood Institute (NHLBI). The vision of CRONICAS is to build a globally[...]texto impreso
Healy, Katherine ; Labrique, Alain B. ; Miranda, J. Jaime ; Gilman, Robert H. ; Danz, David ; Davila-Roman, Victor G. ; Huicho, Luis ; Leon-Velarde, Fabiola ; Checkley, William | Mary Ann Liebert | 2019-02-06T14:45:35ZHealy, Katherine, Alain B. Labrique, J. Jaime Miranda, Robert H. Gilman, David Danz, Victor G. Davila-Roman, Luis Huicho, Fabiola Leon-Velarde, and William Checkley. Dark adaptation at high altitude: an unexpected pupillary response to chronic h[...]texto impreso
Villafuerte, Francisco C. ; Macarlupu, Jose Luis ; Anza-Ramirez, Cecilia ; Corrales-Melgar, Daniela ; Vizcardo-Galindo, Gustavo ; Corante, Noemi ; Leon-Velarde, Fabiola | American Physiological Society | 2020-06-10T18:11:31ZExcessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop EE despite having alt[...]texto impreso
Kiyamu, Melisa ; Leon-Velarde, Fabiola ; Rivera-Chira, Maria ; Elias, Gianpietro ; Brutsaert, Tom D. | Mary Ann Liebert | 2019-02-06T14:52:35ZKiyamu, Melisa, Fabiola Leon-Velarde, Maria Rivera-Chira, Gianpietro Elias, and Tom D. Brutsaert. Developmental effects determine submaximal arterial oxygen saturation in Peruvian Quechua. High Alt Med Biol 16, 138-146, 2015.--Andean high altitu[...]texto impreso
Corante, Noemi ; Anza-Ramirez, Cecilia ; Figueroa-Mujíca, Rómulo ; Macarlupu, Jose Luis ; Vizcardo-Galindo, Gustavo ; Bilo, Grzegorz ; Parati, Gianfranco ; Gamboa, Jorge L. ; Leon-Velarde, Fabiola ; Villafuerte, Francisco C. | Mary Ann Liebert | 2018-11-30T03:10:46ZCorante, Noemí, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L. Gamboa, Fabiola León-Velarde, and Francisco C. Villafuerte. Excessive erythrocytosis and card[...]texto impreso
Ghosh, Sudipta ; Kiyamu, Melisa ; Contreras, Paloma ; Leon-Velarde, Fabiola ; Bigham, Abigail ; Brutsaert, Tom D. | Wiley | 2019-12-06T20:57:51ZOBJECTIVES: Andean and Tibetan high-altitude natives exhibit a high concentration of nitric oxide (NO) in the lungs, suggesting that NO plays an adaptive role in offsetting hypobaric hypoxia. We examined the exhaled NO concentration as well as p[...]texto impreso
Miele, Catherine H. ; Schwartz, Alan R. ; Gilman, Robert H. ; Pham, Luu ; Wise, Robert A. ; Davila-Roman, Victor G. ; Jun, Jonathan C. ; Polotsky, Vsevolod Y. ; Miranda, J. Jaime ; Leon-Velarde, Fabiola ; Checkley, William | Mary Ann Liebert | 2019-02-06T14:45:56ZMiele, Catherine H., Alan R. Schwartz, Robert H. Gilman, Luu Pham, Robert A. Wise, Victor G. Davila-Roman, Jonathan C. Jun, Vsevolod Y. Polotsky, J. Jaime Miranda, Fabiola Leon-Velarde, and William Checkley. Increased cardiometabolic risk and wo[...]texto impreso
Childebayeva, Ainash ; Jones, Tamara R. ; Goodrich, Jaclyn M. ; Leon-Velarde, Fabiola ; Rivera-Chira, Maria ; Kiyamu, Melisa ; Brutsaert, Tom D. ; Dolinoy, Dana C. ; Bigham, Abigail W. | Taylor & Francis | 2019-07-04T17:00:18ZRecent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain the extent of variati[...]texto impreso
Lueneburg, Nicole ; Siques, Patricia ; Brito, Julio ; Arriaza, Karem ; Pena, Eduardo ; Klose, Hans ; Leon-Velarde, Fabiola ; Boeger, Rainer H. | Hindawi Publishing Corporation | 2019-02-22T14:54:33ZChronic intermittent hypoxia (CIH) and chronic hypoxia (CH) are associated with high-altitude pulmonary hypertension (HAPH). Asymmetric dimethylarginine (ADMA), a NO synthase (NOS) inhibitor, may contribute to HAPH. This study assessed changes i[...]texto impreso
Siques, Patricia ; Brito, Julio ; Flores, Karen ; Ordenes, Stefany ; Arriaza, Karem ; Pena, Eduardo ; Leon-Velarde, Fabiola ; Lopez de Pablo, Angel L. ; Gonzalez, M. C. ; Arribas, Silvia | Frontiers Media | 2018-12-01T00:04:14ZBackground: In chronic hypoxia (CH) and short-term chronic intermittent hypoxia (CIH) exposure, glycemia and insulin levels decrease and insulin sensitivity increases, which can be explained by changes in glucose transport at skeletal muscles in[...]texto impreso
Lüneburg, Nicole ; Siques, Patricia ; Brito, Julio ; De La Cruz, Juan Jose ; Leon-Velarde, Fabiola ; Hannemann, Juliane ; Ibanez, Cristian ; Boger, Rainer H. | Mary Ann Liebert | 2019-01-25T15:28:05ZHypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway. We measured[...]texto impreso
Brito, Julio ; Siques, Patricia ; Lopez, Rosario ; Romero, Raúl ; Leon-Velarde, Fabiola ; Flores, Karen ; Lueneburg, Nicole ; Hannemann, Juliane ; Boeger, Rainer H. | Frontiers Media | 2018-12-01T00:04:14ZBackground: Living at high altitude or with chronic hypoxia implies functional and morphological changes in the right ventricle and pulmonary vasculature with a 10% prevalence of high-altitude pulmonary hypertension (HAPH). The implications of w[...]
