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Orr, Jeremy E. ; Heinrich, Erica C. ; Djokic, Matea ; Gilbertson, Dillon ; DeYoung, Pamela N. ; Anza-Ramirez, Cecilia ; Villafuerte, Francisco C. ; Powell, Frank L. ; Malhotra, Atul ; Simonson, Tatum | Mary Ann Liebert | 2018-11-30T02:09:29ZOrr, Jeremy E., Erica C. Heinrich, Matea Djokic, Dillon Gilbertson, Pamela N. Deyoung, Cecilia Anza-Ramirez, Francisco C. Villafuerte, Frank L. Powell, Atul Malhotra, and Tatum Simonson. Adaptive servoventilation as treatment for central sleep a[...]texto impreso
Bilo, Grzegorz ; Villafuerte, Francisco C. ; Faini, Andrea ; Anza-Ramirez, Cecilia ; Revera, Miriam ; Giuliano, Andrea ; Caravita, Sergio ; Gregorini, Francesca ; Lombardi, Carolina ; Salvioni, Elisabetta ; Macarlupu, Jose Luis ; Ossoli, Deborah ; Landaveri, Leah ; Lang, Morin ; Agostoni, Piergiuseppe ; Sosa, Jose Manuel ; Mancia, Giuseppe ; Parati, Gianfranco | American Heart Association | 2019-02-06T14:52:36ZUNLABELLED: Blood pressure increases during acute exposure to high altitude in healthy humans. However, little is known on altitude effects in hypertensive subjects or on the treatment efficacy in this condition. Objectives of High Altitude Card[...]texto impreso
Villafuerte, Francisco C. ; Macarlupu, Jose Luis ; Anza-Ramirez, Cecilia ; Corrales-Melgar, Daniela ; Vizcardo-Galindo, Gustavo ; Corante, Noemi ; Leon-Velarde, Fabiola | American Physiological Society | 2020-06-10T18:11:31ZExcessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop EE despite having alt[...]texto impreso
Corante, Noemi ; Anza-Ramirez, Cecilia ; Figueroa-Mujíca, Rómulo ; Macarlupu, Jose Luis ; Vizcardo-Galindo, Gustavo ; Bilo, Grzegorz ; Parati, Gianfranco ; Gamboa, Jorge L. ; Leon-Velarde, Fabiola ; Villafuerte, Francisco C. | Mary Ann Liebert | 2018-11-30T03:10:46ZCorante, Noemí, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L. Gamboa, Fabiola León-Velarde, and Francisco C. Villafuerte. Excessive erythrocytosis and card[...]texto impreso
Heinrich, Erica C. ; Wu, Lu ; Lawrence, Elijah S. ; Cole, Amy M. ; Anza-Ramirez, Cecilia ; Villafuerte, Francisco C. ; Simonson, Tatum S. | Wiley | 2019-07-04T16:59:37ZEGLN1 encodes the hypoxia-inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen-sensitive regulator of HIF activity. The EGLN1 locus exhibits a signature of positive selection in Tibetan and Andean populations and i[...]texto impreso
Tremblay, Joshua C. ; Hoiland, Ryan L. ; Howe, Connor A. ; Coombs, Geoff B. ; Vizcardo-Galindo, Gustavo A. ; Figueroa-Mujica, Romulo J. ; Bermudez, Daniela ; Gibbons, Travis D. ; Stacey, Benjamin S. ; Bailey, Damian M. ; Tymko, Michael M. ; MacLeod, David B. ; Gasho, Chris ; Villafuerte, Francisco C. ; Pyke, Kyra E. ; Ainslie, Philip N. | American Heart Association | 2019-12-06T20:57:40ZExcessive erythrocytosis (EE; hemoglobin concentration [Hb] > /=21 g/dL in adult males) is associated with increased cardiovascular risk in highlander Andeans. We sought to quantify shear stress and assess endothelial function via flow-mediated [...]texto impreso
Tremblay, Joshua C. ; Coombs, Geoff B. ; Howe, Connor A. ; Vizcardo-Galindo, Gustavo A. ; Figueroa-Mujica, Romulo J. ; Bermudez, Daniela ; Tymko, Michael M. ; Villafuerte, Francisco C. ; Ainslie, Philip N. ; Pyke, Kyra E. | American Physiological Society | 2019-12-06T21:04:46ZExcessive erythrocytosis [EE; hemoglobin concentration (Hb) > /= 21 g/dL in adult men] is a maladaptive high-altitude pathology associated with increased cardiovascular risk and reduced reactive hyperemia flow-mediated dilation (FMD); however,[...]texto impreso
Busch, Stephen A. ; van Diepen, Sean ; Steele, Andrew R. ; Meah, Victoria L. ; Simpson, Lydia L. ; Figueroa-Mujica, Romulo J. ; Vizcardo-Galindo, Gustavo ; Villafuerte, Francisco C. ; Tymko, Michael M. ; Ainslie, Philip N. ; Moore, Jonathan P. ; Stembridge, Mike ; Steinback, Craig D. | Frontiers Media | 2020-07-14T00:00:59ZBackground: Ascent to altitude increases the prevalence of arrhythmogenesis in low-altitude dwelling populations (Lowlanders). High altitude populations (i.e., Nepalese Sherpa) may have arrhythmias resistant adaptations that prevent arrhythmogen[...]texto impreso
Heinrich, Erica C. ; Gaio, Eduardo ; Powell, Frank L. ; Macarlupu, Jose Luis ; Anza-Ramirez, Cecilia ; Corante, Noemi ; Vizcardo-Galindo, Gustavo ; Villafuerte, Francisco C. ; Simonson, Tatum S. | Federation of American Society of Experimental Biology | 2019-02-22T14:54:31ZMultiple adaptive phenotypes for high-altitude and hypoxic stress have developed by distinct evolutionary trajectories in highland populations. For example, considerable variation is observed in the hypoxic ventilatory response (HVR) of Tibetans[...]texto impreso
Bermudez, Daniela ; Azad, Priti ; Figueroa-Mujíca, Rómulo ; Vizcardo-Galindo, Gustavo ; Corante, Noemi ; Guerra-Giraldez, Cristina ; Haddad, Gabriel G. ; Villafuerte, Francisco C. | American Physiological Society | 2020-07-14T00:00:56ZExcessive erythrocytosis (EE) is the main sign of chronic mountain sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism of EE is still controversial, [...]texto impreso
Bermudez, Daniela ; Azad, Priti ; Figueroa-Mujíca, Rómulo ; Vizcardo-Galindo, Gustavo ; Corante, Noemi ; Guerra-Giraldez, Cristina ; Haddad, Gabriel G. ; Villafuerte, Francisco C. | American Physiological Society | 2019-12-06T20:57:40ZExcessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism of EE is still controversial, [...]texto impreso
In the last few years, genetic and functional studies have provided important insight on the pathophysiology of excessive erythrocytosis (EE), the main sign of Chronic Mountain Sickness (CMS). The recent finding of the association of the CMS phe[...]texto impreso
Heinrich, Erica C. ; Orr, Jeremy E. ; Gilbertson, Dillon ; Anza-Ramirez, Cecilia ; DeYoung, Pamela N. ; Djokic, Matea A. ; Corante, Noemi ; Vizcardo-Galindo, Gustavo ; Macarlupu, Jose L. ; Gaio, Eduardo ; Powell, Frank L. ; Malhotra, Atul ; Villafuerte, Francisco C. ; Simonson, Tatum S. | Frontiers Media | 2020-07-14T00:01:15ZAndean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations. While many Andeans develop Chronic Mountain Sickness (CMS) and excessive erythro[...]texto impreso
Macarlupu, Jose L. ; Vizcardo-Galindo, Gustavo ; Figueroa-Mujíca, Rómulo ; Villafuerte, Francisco C. | Federation of American Society of Experimental Biology | 2020-07-14T00:02:32ZExcessive erythrocytosis (EE; Hct ? 63% in men) is the hallmark of Monge?s disease or Chronic Mountain Sickness (CMS), a debilitating syndrome with high prevalence in Andean highlanders. EE is associated with typical CMS neurological symptoms an[...]texto impreso
Gazal, Steven ; Espinoza, Jose R. ; Austerlitz, Frederic ; Marchant, Dominique ; Macarlupu, Jose Luis ; Rodriguez, Jorge ; Ju-Preciado, Hugo ; Rivera-Chira, Maria ; Hermine, Olivier ; Leon-Velarde, Fabiola ; Villafuerte, Francisco C. ; Richalet, Jean-Paul ; Gouya, Laurent | Frontiers Media | 2019-12-06T20:57:51ZChronic mountain sickness (CMS) is a pathological condition resulting from chronic exposure to high-altitude hypoxia. While its prevalence is high in native Andeans (> 10%), little is known about the genetic architecture of this disease. Here, w[...]
