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Tift, M.S. ; Alves de Souza, R.W. ; Weber, J. ; Heinrich, E.C. ; Villafuerte, F.C. ; Malhotra, A. ; Otterbein, L.E. ; Simonson, T.S. | Frontiers Media S.A. | 2020-12-14T16:10:18ZHeme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemi[...]texto impreso
Heinrich, E.C. ; Wu, L. ; Lawrence, E.S. ; Cole, A.M. ; Anza-Ramirez, C. ; Villafuerte, F.C. ; Simonson, T.S. | Wiley | 2019-12-06T20:57:49ZEGLN1 encodes the hypoxia-inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen-sensitive regulator of HIF activity. The EGLN1 locus exhibits a signature of positive selection in Tibetan and Andean populations and i[...]texto impreso
Steele, A.R. ; Tymko, M.M. ; Meah, V.L. ; Simpson, L.L. ; Gasho, C. ; Dawkins, T.G. ; Villafuerte, F.C. ; Ainslie, P.N. ; Stembridge, M. ; Moore, J.P. ; Steinback, C.D. | NLM (Medline) | 2020-12-14T16:10:15ZEarly acclimatization to high altitude is characterized by various respiratory, hematological, and cardiovascular adaptations that serve to restore oxygen delivery to tissue. However, less is understood about renal function and the role of renal[...]texto impreso
Vizcardo-Galindo, G. ; León-Velarde, F. ; Villafuerte, F.C. | Mary Ann Liebert Inc. | 2020-12-14T16:11:08ZBackground: The soluble form of the erythropoietin (Epo) receptor (sEpoR) is an endogenous antagonist of Epo. Decreasing plasma sEpoR increases free Epo, thereby increasing the availability of the hormone. In humans, short-term intermittent norm[...]
