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Prajapati, Surendra Kumar ; Borlon, Celine ; Rovira-Vallbona, Eduard ; Gruszczyk, Jakub ; Menant, Sebastien ; Tham, Wai-Hong ; Kattenberg, Johanna Helena ; Villasis, Elizabeth ; De Meulenaere, Katlijn ; Gamboa, Dionicia ; Vinetz, Joseph ; Fujita, Ricardo ; Xuan, Xa Nguyen ; Urbano Ferreira, Marcelo ; Nino, Carlos H. ; Patarroyo, Manuel A. ; Spanakos, Gregory ; Kestens, Luc ; Abbeele, Jan Van Den ; Rosanas-Urgell, Anna | Nature Research | 2019-07-04T16:59:26ZPlasmodium vivax parasites preferentially invade reticulocyte cells in a multistep process that is still poorly understood. In this study, we used ex vivo invasion assays and population genetic analyses to investigate the involvement of compleme[...]texto impreso
Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.
Knuepfer, Ellen ; Wright, Katherine E. ; Kumar Prajapati, Surendra ; Rawlinson, Thomas A. ; Mohring, Franziska ; Koch, Marion ; Lyth, Oliver R. ; Howell, Steven A. ; Villasis, Elizabeth ; Snijders, Ambrosius P. ; Moon, Robert W. ; Draper, Simon J. ; Rosanas-Urgell, Anna ; Higgins, Matthew K. ; Baum, Jake ; Holder, Anthony A. | Public Library of Science | 2019-12-06T21:02:54ZMalaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR [...]texto impreso
Knuepfer, Ellen ; Wright, Katherine E. ; Kumar Prajapati, Surendra ; Rawlinson, Thomas A. ; Mohring, Franziska ; Koch, Marion ; Lyth, Oliver R. ; Howell, Steven A. ; Villasis, Elizabeth ; Snijders, Ambrosius P. ; Moon, Robert W. ; Draper, Simon J. ; Rosanas-Urgell, Anna ; Higgins, Matthew K. ; Baum, Jake ; Holder, Anthony A. | Public Library of Science | 2019-07-04T16:59:29ZMalaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR [...]texto impreso
Rosas-Aguirre, Angel ; Speybroeck, Niko ; Llanos-Cuentas, Alejandro ; Rosanas-Urgell, Anna ; Carrasco-Escobar, Gabriel ; Rodriguez, Hugo ; Gamboa, Dionicia ; Contreras-Mancilla, Juan ; Alava, Freddy ; Soares, Irene S. ; Remarque, Edmond ; D Alessandro, Umberto ; Erhart, Annette | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: With low and markedly seasonal malaria transmission, increasingly sensitive tools for better stratifying the risk of infection and targeting control interventions are needed. A cross-sectional survey to characterize the current malar[...]texto impreso
Serra-Casas, Elisa ; Manrique, Paulo ; Ding, Xavier C. ; Carrasco-Escobar, Gabriel ; Alava, Freddy ; Gave, Anthony ; Rodriguez, Hugo ; Contreras-Mancilla, Juan ; Rosas-Aguirre, Angel ; Speybroeck, Niko ; Gonzalez, Iveth J. ; Rosanas-Urgell, Anna ; Gamboa, Dionicia | Public Library of Science | 2019-01-25T15:28:05ZBACKGROUND: Loop-mediated isothermal DNA amplification (LAMP) methodology offers an opportunity for point-of-care (POC) molecular detection of asymptomatic malaria infections. However, there is still little evidence on the feasibility of impleme[...]texto impreso
Rosas-Aguirre, Angel ; Erhart, Annette ; Llanos-Cuentas, Alejandro ; Branch, Oralee ; Berkvens, Dirk ; Abatih, Emmanuel ; Lambert, Philippe ; Frasso, Gianluca ; Rodriguez, Hugo ; Gamboa, Dionicia ; Sihuincha, Moises ; Rosanas-Urgell, Anna ; D'Alessandro, Umberto ; Speybroeck, Niko | BMC | 2019-02-06T14:53:08ZBACKGROUND: Focal screening and treatment (FSAT) of malaria infections has recently been introduced in Peru to overcome the inherent limitations of passive case detection (PCD) and further decrease the malaria burden. Here, we used a relatively[...]texto impreso
Serra-Casas, Elisa ; Guetens, Pieter ; Chiheb, Driss ; Gamboa, Dionicia ; Rosanas-Urgell, Anna | Elsevier | 2019-12-06T21:04:41ZHighly-sensitive and field-friendly diagnostic tools are needed for accurate detection of low-density malaria infections. Although loop-mediated isothermal amplification (LAMP) fulfills these conditions, operational challenges are still encount[...]texto impreso
Pham, Thanh Vinh ; Nguyen, Hong Van ; Aguirre, Angel Rosas ; Nguyen, Van Van ; A Cleves, Mario ; Nguyen, Xa Xuan ; Nguyen, Thao Thanh ; Tran, Duong Thanh ; Le, Hung Xuan ; Hens, Niel ; Rosanas-Urgell, Anna ; D'Alessandro, Umberto ; Speybroeck, Niko ; Erhart, Annette | Public Library of Science | 2019-07-04T17:00:20ZBACKGROUND: In Vietnam, the importance of vivax malaria relative to falciparum during the past decade has steadily increased to 50%. This, together with the spread of multidrug-resistant Plasmodium falciparum, is a major challenge for malaria el[...]texto impreso
Delgado-Ratto, Christopher ; Gamboa, Dionicia ; Soto-Calle, Veronica-E. ; Van-den-Eede, Peter ; Torres, Eliana ; Sanchez-Martinez, Luis ; Contreras-Mancilla, Juan ; Rosanas-Urgell, Anna ; Rodriguez-Ferrucci, Hugo ; Llanos-Cuentas, Alejandro ; Erhart, Annette ; Van-Geertruyden, Jean-Pierre ; D'Alessandro, Umberto | Public Library of Science | 2019-02-06T14:45:12ZBACKGROUND: Characterizing the parasite dynamics and population structure provides useful information to understand the dynamic of transmission and to better target control interventions. Despite considerable efforts for its control, vivax malar[...]texto impreso
Rovira-Vallbona, Eduard ; Contreras-Mancilla, Juan José ; Ramirez, Roberson ; Guzmán-Guzmán, Mitchel ; Carrasco-Escobar, Gabriel ; Llanos-Cuentas, Alejandro ; Vinetz, Joseph M. ; Gamboa, Dionicia ; Rosanas-Urgell, Anna | Public Library of Science | 2019-01-25T15:28:08ZMalaria transmission requires that Anopheles mosquitoes ingest Plasmodium gametocyte stages circulating in the human bloodstream. In the context of malaria elimination, understanding the epidemiology of gametocytes relative to all Plasmodium inf[...]texto impreso
Soto-Calle, Veronica ; Rosas-Aguirre, Angel ; Llanos-Cuentas, Alejandro ; Abatih, Emmanuel ; DeDeken, Redgi ; Rodriguez, Hugo ; Rosanas-Urgell, Anna ; Gamboa, Dionicia ; D Alessandro, Umberto ; Erhart, Annette ; Speybroeck, Niko | Nature Research | 2019-01-25T16:03:21ZMalaria remains a major public health problem in the Peruvian Amazon where the persistence of high-risk transmission areas (hotspots) challenges the current malaria control strategies. This study aimed at identifying significant space-time clust[...]
