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Llanos-Cuentas, Alejandro ; Casapía, Martin ; Chuquiyauri, Raúl ; Hinojosa, Juan-Carlos ; Kerr, Nicola ; Rosario, Maria ; Toovey, Stephen ; Arch, Robert H. ; Phillips, Margaret A. ; Rozenberg, Felix D. ; Bath, Jade ; Ng, Caroline L. ; Cowell, Annie N. ; Winzeler, Elizabeth A. ; Fidock, David A. ; Baker, Mark ; Möhrle, Jörg J. ; Hooft van Huijsduijnen, Rob ; Gobeau, Nathalie ; Araeipour, Nada ; Andenmatten, Nicole ; Rückle, Thomas ; Duparc, Stephan | Elsevier | 2018-11-30T02:09:29ZBACKGROUND: DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against blood and liver stages of Plasmodium falciparum. This study aimed to asses[...]texto impreso
Adaui, Vanessa ; Lye, Lon-Fye ; Akopyants, Natalia S. ; Zimic, Mirko ; Llanos-Cuentas, Alejandro ; Garcia, Lineth ; Maes, Ilse ; De Doncker, Simonne ; Dobson, Deborah E. ; Arevalo, Jorge ; Dujardin, Jean-Claude ; Beverley, Stephen M. | Oxford University Press | 2019-02-06T14:57:40ZCutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with resistance in vitro, and th[...]texto impreso
Martínez, Dalila Y. ; Llanos-Cuentas, Alejandro ; Dujardin, Jean-Claude ; Polman, Katja ; Adaui, Vanessa ; Boelaert, Marleen ; Verdonck, Kristien | Oxford University Press | 2020-07-14T00:02:33ZBACKGROUND: Endemic regions of cutaneous leishmaniasis (CL) and intestinal helminthiasis overlap. CL treatment with systemic pentavalent antimonial drugs (Sb(5+)) fails in 10%-30% of patients. The study objective was to assess the etiological ro[...]texto impreso
Llanos-Chea, Fiorella ; Martinez, Dalila ; Rosas, Angel ; Samalvides, Frine ; Vinetz, Joseph M. ; Llanos-Cuentas, Alejandro | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:37ZSevere Plasmodium falciparum malaria is uncommon in South America. Lima, Peru, while not endemic for malaria, is home to specialized centers for infectious diseases that admit and manage patients with severe malaria (SM), all of whom contracted [...]texto impreso
Sherman, Mya ; Berrang-Ford, Lea ; Lwasa, Shuaib ; Ford, James ; Namanya, Didacus B. ; Llanos-Cuentas, Alejandro ; Maillet, Michelle ; Harper, Sherilee ; Team, IHACC Res | Wiley | 2019-02-22T14:56:09ZClimate change adaptation is increasingly considered an urgent priority for policy action. Billions of dollars have been pledged for adaptation finance, with many donor agencies requiring that adaptation is distinct from baseline development. Ho[...]texto impreso
Moreno-Gutierrez, Diamantina ; Rosas-Aguirre, Angel ; Llanos-Cuentas, Alejandro ; Bilcke, Joke ; Barboza, José Luis ; Hayette, Marie-Pierre ; Contreras-Mancilla, Juan ; Aguirre, Kristhian ; Gamboa, Dionicia ; Rodriguez, Hugo ; Speybroeck, Niko ; Beutels, Philippe | BMC | 2020-07-14T00:02:35ZBackground: Case management is one of the principal strategies for malaria control. This study aimed to estimate the economic costs of uncomplicated malaria case management and explore the influence of health-seeking behaviours on those costs. M[...]texto impreso
Moreno-Gutierrez, Diamantina ; Llanos-Cuentas, Alejandro ; Luis Barboza, Jose ; Contreras-Mancilla, Juan ; Gamboa, Dionicia ; Rodriguez, Hugo ; Carrasco-Escobar, Gabriel ; Boreux, Raphael ; Hayette, Marie-Pierre ; Beutels, Philippe ; Speybroeck, Niko ; Rosas-Aguirre, Angel | MDPI | 2019-03-05T15:23:27ZBackground: Faced with the resurgence of malaria, malaria surveillance in the Peruvian Amazon incorporated consecutive active case detection (ACD) interventions using light microscopy (LM) as reactive measure in communities with an unusual high [...]texto impreso
Rosas-Aguirre, Angel ; Gamboa, Dionicia ; Manrique, Paulo ; Conn, Jan-E. ; Moreno, Marta ; Lescano, Andres-G. ; Sanchez, Juan-F. ; Rodriguez, Hugo ; Silva, Hermann ; Llanos-Cuentas, Alejandro ; Vinetz, Joseph-M. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:58ZMalaria in Peru, dominated by Plasmodium vivax, remains a public health problem. The 1990s saw newly epidemic malaria emerge, primarily in the Loreto Department in the Amazon region, including areas near to Iquitos, the capital city, but sporad[...]texto impreso
Beck, Hans-Peter ; Wampfler, Rahel ; Carter, Nick ; Koh, Gavin ; Osorio, Lyda ; Rueangweerayut, Ronnatrai ; Krudsood, Srivcha ; Lacerda, Marcus V. ; Llanos-Cuentas, Alejandro ; Duparc, Stephan ; Rubio, Justin P. ; Green, Justin A. | Oxford University Press | 2019-02-06T14:57:40ZUNLABELLED: Prevention of relapse of Plasmodium vivax infection is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled phase 2b study in Peru, India, Thailand, and Brazil all[...]texto impreso
Ochoa, Theresa J. ; Baiocchi, Nelly ; Valdiviezo, Gladys ; Bullon, Vanessa ; Campos, Miguel ; Llanos-Cuentas, Alejandro | Cambridge University Press | 2019-01-25T15:18:34ZOBJECTIVE: To determine the effect of a fish protein isolate (FPi), administered over 6 months, on the growth of children aged 6-36 months, measured by Z-scores of height-for-age (HAZ) and weight-for-height (WHZ), compared with the standard meal[...]texto impreso
Sherman, Mya ; Ford, James ; Llanos-Cuentas, Alejandro ; Valdivia, Maria Jose ; Indigenous Health Adaptation to Climate Change Research Group | Springer | 2019-02-22T14:55:28ZProjections of climate change indicate an increase in the frequency and intensity of climatic hazards such as flooding and droughts, increasing the importance of understanding community vulnerability to extreme hydrological events. This research[...]texto impreso
Chuquiyauri, Raúl ; Molina, Douglas M. ; Moss, Eli L. ; Wang, Ruobing ; Gardner, Malcolm J. ; Brouwer, Kimberly C. ; Torres, Sonia ; Gilman, Robert H. ; Llanos-Cuentas, Alejandro ; Neafsey, Daniel E. ; Felgner, Philip ; Liang, Xiaowu ; Vinetz, Joseph M. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:38ZLarge scale antibody responses in Plasmodium vivax malaria remains unexplored in the endemic setting. Protein microarray analysis of asexual-stage P. vivax was used to identify antigens recognized in sera from residents of hypoendemic Peruvian [...]texto impreso
Olliaro, Piero ; Grogl, Max ; Boni, Marina ; Carvalho, Edgar M. ; Chebli, Houda ; Cissé, Mamoudou ; Diro, Ermias ; Cota, Gláucia Fernandes ; Erber, Astrid C. ; Gadisa, Endalamaw ; Handjani, Farhad ; Khamesipour, Ali ; Llanos-Cuentas, Alejandro ; Carvajal, Liliana López ; Grout, Lise ; Lmimouni, Badre Eddine ; Mokni, Mourad ; Nahzat, Mohammad Sami ; Salah, Afif Ben ; Ozbel, Yusuf ; Pascale, Juan Miguel ; Molina, Nidia Rizzo ; Rode, Joelle ; Romero, Gustavo ; Ruiz-Postigo, José Antonio ; Saravia, Nancy Gore ; Soto, Jaime ; Uzun, Soner ; Mashayekhi, Vahid ; Vélez, Ivan Dario ; Vogt, Florian ; Zerpa, Olga ; Arana, Byron | Public Library of Science | 2018-06-18T15:26:49ZIntroduction Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over the years has generated only weak evidence backi[...]texto impreso
Carrasco-Escobar, Gabriel ; Miranda-Alban, Julio ; Fernandez-Minope, Carlos ; Brouwer, Kimberly C. ; Torres, Katherine ; Calderón, Maritza ; Gamboa, Dionicia ; Llanos-Cuentas, Alejandro ; Vinetz, Joseph M. | BMC | 2019-01-25T15:18:36ZBACKGROUND: The incidence of malaria due both to Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon has risen in the past 5 years. This study tested the hypothesis that the maintenance and emergence of malaria in hypoendemic regio[...]texto impreso
Rosas-Aguirre, Angel ; Speybroeck, Niko ; Llanos-Cuentas, Alejandro ; Rosanas-Urgell, Anna ; Carrasco-Escobar, Gabriel ; Rodriguez, Hugo ; Gamboa, Dionicia ; Contreras-Mancilla, Juan ; Alava, Freddy ; Soares, Irene S. ; Remarque, Edmond ; D Alessandro, Umberto ; Erhart, Annette | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: With low and markedly seasonal malaria transmission, increasingly sensitive tools for better stratifying the risk of infection and targeting control interventions are needed. A cross-sectional survey to characterize the current malar[...]
