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Sempou, Emily ; Biasini, Emiliano ; Pinzon-Olejua, Alejandro ; Harris, David-A. ; Malaga-Trillo, Edward | BMC | 2019-02-06T14:45:59ZBACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals cont[...]texto impreso
Prions and Amyloid beta (Abeta) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrP(C)) acts as a high-affinity cell su[...]
