Información del autor
Documentos disponibles escritos por este autor (22)
Añadir el resultado a su cesta Hacer una sugerencia Refinar búsqueda
texto impreso
Lopez-Garnier, Santiago ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-07-04T16:59:21ZTuberculosis is an infectious disease that causes ill health and death in millions of people each year worldwide. Timely diagnosis and treatment is key to full patient recovery. The Microscopic Observed Drug Susceptibility (MODS) is a test to d[...]texto impreso
Lopez, Juan M. ; Antiparra, Ricardo ; Lippens, Guy ; Zimic, Mirko ; Sheen, Patricia ; Maruenda, Helena | Springer | 2018-11-30T02:09:30ZChagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the[...]texto impreso
León-Janampa, Nancy ; Liendo, Ruddy ; Gilman, Robert H. ; Padilla, Carlos ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Pajuelo, Monica J. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Elsevier | 2019-07-04T16:59:24ZPorcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, identification and characteriza[...]texto impreso
Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Marin, Lisette ; Kirwan, Daniela E. ; Gilman, Robert H. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2020-07-14T00:00:54ZPyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens, due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is considered sufficiently rel[...]texto impreso
Solis, Leonardo ; Coronel, Jorge ; Rueda, Daniel ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Elsevier | 2019-02-06T14:57:42ZTuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and novel diagnostic approache[...]texto impreso
Coronel, Jorge E. ; Del Carpio, Christian C. ; Dianderas, Erwin J. ; Florentini, Edgar A. ; Kemper, Guillermo L. ; Sheen, Patricia ; Zimic, Mirko J. | Medknow Publications | 2019-07-04T16:59:33ZBackground: Direct sputum smear is still the first-choice tool for screening of tuberculosis worldwide. Variants of this technique, to improve the sensitivity are desired. Methods: Two microbiological variants of the standard sputum smear ("pell[...]texto impreso
Pajuelo, Monica J. ; Eguiluz, María ; Roncal, Elisa ; Quiñones-García, Stefany ; Clipman, Steven J. ; Calcina, Juan ; Gavidia, Cesar M. ; Sheen, Patricia ; Garcia, Hector H. ; Gilman, Robert H. ; Gonzalez, Armando E. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Public Library of Science | 2019-01-25T15:18:36ZThe adult Taenia solium, the pork tapeworm, usually lives as a single worm in the small intestine of humans, its only known definitive host. Mechanisms of genetic variation in T. solium are poorly understood. Using three microsatellite markers p[...]texto impreso
Coll, Francesc ; Phelan, Jody ; Hill-Cawthorne, Grant A. ; Nair, Mridul B. ; Mallard, Kim ; Ali, Shahjahan ; Abdallah, Abdallah M. ; Alghamdi, Saad ; Alsomali, Mona ; Ahmed, Abdallah O. ; Portelli, Stephanie ; Oppong, Yaa ; Alves, Adriana ; Bessa, Theolis Barbosa ; Campino, Susana ; Caws, Maxine ; Chatterjee, Anirvan ; Crampin, Amelia C. ; Dheda, Keertan ; Furnham, Nicholas ; Glynn, Judith R. ; Grandjean, Louis ; Minh Ha, Dang ; Hasan, Rumina ; Hasan, Zahra ; Hibberd, Martin L. ; Joloba, Moses ; Jones-López, Edward C. ; Matsumoto, Tomoshige ; Miranda, Anabela ; Moore, David J. ; Mocillo, Nora ; Panaiotov, Stefan ; Parkhill, Julian ; Penha, Carlos ; Perdigão, João ; Portugal, Isabel ; Rchiad, Zineb ; Robledo, Jaime ; Sheen, Patricia ; Shesha, Nashwa Talaat ; Sirgel, Frik A. ; Sola, Christophe ; Oliveira Sousa, Erivelton ; Streicher, Elizabeth M. ; Helden, Paul Van ; Viveiros, Miguel ; Warren, Robert M. ; McNerney, Ruth ; Pain, Arnab ; Clark, Taane G. | Nature Research | 2018-11-30T03:10:47ZTo characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mix[...]texto impreso
Pajuelo, Monica J. ; Eguiluz, María ; Dahlstrom, Eric ; Requena, David ; Guzman, Frank ; Ramírez, Manuel ; Sheen, Patricia ; Frace, Michael ; Sammons, Scott ; Cama, Vitaliano ; Anzick, Sarah ; Bruno, Dan ; Mahanty, Siddhartha ; Wilkins, Patricia ; Nash, Theodore ; Gonzalez, Armando ; Garcia, Hector H. ; Gilman, Robert H. ; Porcella, Steve ; Zimic, Mirko | Public Library of Science | 2019-02-06T14:53:08ZBACKGROUND: Infections with Taenia solium are the most common cause of adult acquired seizures worldwide, and are the leading cause of epilepsy in developing countries. A better understanding of the genetic diversity of T. solium will improve p[...]texto impreso
Warren, Joshua L. ; Grandjean, Louis ; Moore, David A. J. ; Lithgow, Anna ; Coronel, Jorge ; Sheen, Patricia ; Zelner, Jonathan L. ; Andrews, Jason R. ; Cohen, Ted | BMC | 2018-11-30T17:17:14ZBACKGROUND: Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods s[...]texto impreso
Alva, Alicia ; Cangalaya, Carla ; Quiliano, Miguel ; Krebs, Casey ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-01-25T15:28:05ZParasitic infections are generally diagnosed by professionals trained to recognize the morphological characteristics of the eggs in microscopic images of fecal smears. However, this laboratory diagnosis requires medical specialists which are lac[...]texto impreso
Salazar-Salinas, Karim ; Baldera-Aguayo, Pedro A. ; Encomendero-Risco, Jimy J. ; Orihuela, Melvin ; Sheen, Patricia ; Seminario, Jorge M. ; Zimic, Mirko | American Chemical Society | 2020-06-10T18:12:14ZMycobacterium tuberculosis pyrazinamidase (PZAse) is a key enzyme to activate the pro-drug pyrazinamide (PZA). PZAse is a metalloenzyme that coordinates in vitro different divalent metal cofactors in the metal coordination site (MCS). Several m[...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Antiparra, Ricardo ; Santos, Marco ; Gilman, Robert H. ; Kirwan, Daniela E. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2018-11-30T17:17:15ZAlthough pyrazinamide (PZA) is a key component of first and second line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of extens[...]texto impreso
Sheen, Patricia ; Requena, David ; Gushiken, Eduardo ; Gilman, Robert H. ; Antiparra, Ricardo ; Lucero, Bryan ; Lizárraga, Pilar ; Cieza, Basilio ; Roncal, Elisa ; Grandjean, Louis ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane G. ; Moore, David ; Zimic, Mirko | BMC | 2019-01-25T15:02:14ZBACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its comple[...]
