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Bazin, Marc-Antoine ; Rousseau, Benedicte ; Marhadour, Sophie ; Tomasoni, Christophe ; Evenou, Pierre ; Piessard, Sylvie ; Vaisberg, Abraham J. ; Ruchaud, Sandrine ; Bach, Stephane ; Roussakis, Christos ; Marchand, Pascal | International Institute of Anticancer Research | 2019-02-22T14:54:00ZA series of (imidazo[1,2-a]pyrazin-6-yl)ureas were synthesized through 6-aminoimidazo[1,2-a]pyrazine as a key intermediate. 1-(Imidazo[1,2-a]pyrazin-6-yl)-3-(4-methoxy-phenyl) urea displayed a cytostatic activity against a nonsmall cell lung can[...]texto impreso
Stivers, Nicole S. ; Islam, Ashraful ; Reyes-Reyes, Elsa M. ; Casson, Lavona K. ; Aponte, José C. ; Vaisberg, Abraham J. ; Hammond, Gerald B. ; Bates, Paula J. | MDPI | 2018-11-30T22:50:35ZWe previously reported on the isolation and biological activities of plagiochiline A (1), a 2,3-secoaromadendrane-type sesquiterpenoid from the Peruvian medicinal plant, Plagiochila disticha. This compound was found to have antiproliferative eff[...]texto impreso
Marchand, Pascal ; Bazin, Marc-Antoine ; Pagniez, Fabrice ; Riviere, Guillaume ; Bodero, Lizeth ; Marhadour, Sophie ; Nourrisson, Marie-Renee ; Picot, Carine ; Ruchaud, Sandrine ; Bach, Stephane ; Baratte, Blandine ; Sauvain, Michel ; Pareja, Denis Castillo ; Vaisberg, Abraham J. ; Le Pape, Patrice | Elsevier | 2019-02-06T14:52:34ZA series of original 2-phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyrazines and the 3-iodo precursors, bearing a polar moiety at the C-8 position, was synthesized and evaluated for their antileishmanial activities. Two derivatives exhibited very good [...]
