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St Jean, P.L. ; Koh, G.C.K.W. ; Breton, J.J. ; Espino, F.E.J. ; Hien, T.T. ; Krudsood, S. ; Lacerda, M.V.G. ; Llanos-Cuentas, A. ; Lon, C. ; Mohammed, R. ; Namaik-Larp, C.S. ; Pereira, D.B. ; Saunders, D.L. ; Velez, I.D. ; Yilma, D. ; Villegas, M.F. ; Duparc, S. ; Green, J.A. | Lippincott Williams and Wilkins | 2020-12-14T16:10:15ZPlasmodium vivax has the largest geographic range of human malaria species and is challenging to manage and eradicate due to its ability to establish a dormant liver stage, the hypnozoite, which can reactivate leading to relapse. Until recently,[...]texto impreso
Lacerda, M.V.G. ; Llanos-Cuentas, A. ; Krudsood, S. ; Lon, C. ; Saunders, D.L. ; Mohammed, R. ; Yilma, D. ; Pereira, D.B. ; Espino, F.E.J. ; Mia, R.Z. ; Chuquiyauri, R. ; Val, F. ; Casapía, M. ; Monteiro, W.M. ; Brito, M.A.M. ; Costa, M.R.F. ; Buathong, N. ; Noedl, H. ; Diro, E. ; Getie, S. ; Wubie, K.M. ; Abdissa, A. ; Zeynudin, A. ; Abebe, C. ; Tada, M.S. ; Brand, F. ; Beck, H.-P. ; Angus, B. ; Duparc, S. ; Kleim, J.-P. ; Kellam, L.M. ; Rousell, V.M. ; Jones, S.W. ; Hardaker, E. ; Mohamed, K. ; Clover, D.D. ; Fletcher, K. ; Breton, J.J. ; Ugwuegbulam, C.O. ; Green, J.A. ; Koh, G.C.K.W. | Massachusetts Medical Society | 2019-12-06T20:57:48ZBACKGROUND Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed “radical cure”). Tafenoquine is a single-dose 8-[...]texto impreso
Llanos-Cuentas, A. ; Lacerda, M.V.G. ; Hien, T.T. ; Velez, I.D. ; Namaik-Larp, C. ; Chu, C.S. ; Villegas, M.F. ; Val, F. ; Monteiro, W.M. ; Brito, M.A.M. ; Costa, M.R.F. ; Chuquiyauri, R. ; Casapía, M. ; Nguyen, C.H. ; Aruachan, S. ; Papwijitsil, R. ; Nosten, F.H. ; Bancone, G. ; Angus, B. ; Duparc, S. ; Craig, G. ; Rousell, V.M. ; Jones, S.W. ; Hardaker, E. ; Clover, D.D. ; Kendall, L. ; Mohamed, K. ; Koh, G.C.K.W. ; Wilches, V.M. ; Breton, J.J. ; Green, J.A. | Massachusetts Medical Society | 2019-12-06T20:57:47ZBACKGROUND Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed “radical cure.” METHODS We performed a phase 3, prospec[...]
