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Llanos-Cuentas, Alejandro ; Casapía, Martin ; Chuquiyauri, Raúl ; Hinojosa, Juan-Carlos ; Kerr, Nicola ; Rosario, Maria ; Toovey, Stephen ; Arch, Robert H. ; Phillips, Margaret A. ; Rozenberg, Felix D. ; Bath, Jade ; Ng, Caroline L. ; Cowell, Annie N. ; Winzeler, Elizabeth A. ; Fidock, David A. ; Baker, Mark ; Möhrle, Jörg J. ; Hooft van Huijsduijnen, Rob ; Gobeau, Nathalie ; Araeipour, Nada ; Andenmatten, Nicole ; Rückle, Thomas ; Duparc, Stephan | Elsevier | 2018-11-30T02:09:29ZBACKGROUND: DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against blood and liver stages of Plasmodium falciparum. This study aimed to asses[...]texto impreso
Chuquiyauri, Raúl ; Molina, Douglas M. ; Moss, Eli L. ; Wang, Ruobing ; Gardner, Malcolm J. ; Brouwer, Kimberly C. ; Torres, Sonia ; Gilman, Robert H. ; Llanos-Cuentas, Alejandro ; Neafsey, Daniel E. ; Felgner, Philip ; Liang, Xiaowu ; Vinetz, Joseph M. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:38ZLarge scale antibody responses in Plasmodium vivax malaria remains unexplored in the endemic setting. Protein microarray analysis of asexual-stage P. vivax was used to identify antigens recognized in sera from residents of hypoendemic Peruvian [...]texto impreso
Moreno, Marta ; Tong, Carlos ; Guzman, Mitchel ; Chuquiyauri, Raúl ; Llanos-Cuentas, Alejandro ; Rodriguez, Hugo ; Gamboa, Dionicia ; Meister, Stephan ; Winzeler, Elizabeth A. ; Maguina, Paula ; Conn, Jan E. ; Vinetz, Joseph M. | American Society of Tropical Medicine and Hygiene | 2020-06-10T18:11:37ZAnopheles darlingi Root is the most important malaria vector in the Amazonia region of South America. However, continuous propagation of An. darlingi in the laboratory has been elusive, limiting entomological, genetic/genomic, and vector-pathoge[...]texto impreso
Rosas-Aguirre, Angel ; Guzmán-Guzmán, Mitchel ; Gamboa, Dionicia ; Chuquiyauri, Raúl ; Ramirez, Roberson ; Manrique, Paulo ; Carrasco-Escobar, Gabriel ; Puemape, Carmen ; Llanos-Cuentas, Alejandro ; Vinetz, Joseph M. | BMC | 2019-01-25T15:28:05ZBACKGROUND: Understanding the dynamics of malaria transmission in diverse endemic settings is key for designing and implementing locally adapted and sustainable control and elimination strategies. A parasitological and epidemiological survey was[...]texto impreso
Lacerda, Marcus V. G. ; Llanos-Cuentas, Alejandro ; Krudsood, Srivicha ; Lon, Chanthap ; Saunders, David L. ; Mohammed, Rezika ; Yilma, Daniel ; Batista Pereira, Dhelio ; Espino, Fe E. J. ; Mia, Reginaldo Z. ; Chuquiyauri, Raúl ; Val, Fernando ; Casapía, Martin ; Monteiro, Wuelton M. ; Brito, Marcelo A. M. ; Costa, Monica R. F. ; Buathong, Nillawan ; Noedl, Harald ; Diro, Ermias ; Getie, Sisay ; Wubie, Kalehiwot M. ; Abdissa, Alemseged ; Zeynudin, Ahmed ; Abebe, Cherinet ; Tada, Mauro S. ; Brand, Francoise ; Beck, Hans-Peter ; Angus, Brian ; Duparc, Stephan ; Kleim, Jorg-Peter ; Kellam, Lynda M. ; Rousell, Victoria M. ; Jones, Sion W. ; Hardaker, Elizabeth ; Mohamed, Khadeeja ; Clover, Donna D. ; Fletcher, Kim ; Breton, John J. ; Ugwuegbulam, Cletus O. ; Green, Justin A. ; Koh, Gavin C. K. W. | Massachusetts Medical Society | 2019-07-04T17:00:24ZBACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8[...]texto impreso
Llanos-Cuentas, Alejandro ; Lacerda, Marcus V. G. ; Hien, Tran T. ; Velez, Ivan D. ; Namaik-Larp, Chayadol ; Chu, Cindy S. ; Villegas, Maria F. ; Val, Fernando ; Monteiro, Wuelton M. ; Brito, Marcelo A. M. ; Costa, Monica R. F. ; Chuquiyauri, Raúl ; Casapía, Martin ; Nguyen, Chau H. ; Aruachan, Sandra ; Papwijitsil, Ratchadaporn ; Nosten, Francois H. ; Bancone, Germana ; Angus, Brian ; Duparc, Stephan ; Craig, Graham ; Rousell, Victoria M. ; Jones, Sion W. ; Hardaker, Elizabeth ; Clover, Donna D. ; Kendall, Lindsay ; Mohamed, Khadeeja ; Koh, Gavin C. K. W. ; Wilches, Viviana M. ; Breton, John J. ; Green, Justin A. | Massachusetts Medical Society | 2019-07-04T17:01:20ZBACKGROUND: Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed "radical cure." METHODS: We performed a phase 3, pros[...]
