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Schuler, B. ; Rieger, G. ; Gubser, M. ; Arras, M. ; Gianella, M. ; Vogel, O. ; Jirkof, P. ; Cesarovic, N. ; Klohs, J. ; Jakob, P. ; Brock, M. ; Gorr, T.A. ; Baum, O. ; Hoppeler, H. ; Samillan-Soto, V. ; Gassmann, M. ; Fischer, J.A. ; Born, W. ; Vogel, J. | Wiley | 2020-06-10T18:11:36ZAim: It is unknown how the heart distinguishes various overloads, such as exercise or hypertension, causing either physiological or pathological hypertrophy. We hypothesize that alpha-calcitonin-gene-related peptide (?CGRP), known to be released[...]texto impreso
Moransard, M. ; Bednar, M. ; Frei, K. ; Gassmann, M. ; Ogunshola, O. O. | BMC | 2019-01-25T15:18:34ZBACKGROUND: Treatment with erythropoietin (Epo) in experimental autoimmune encephalomyelitis (EAE), the rodent model of multiple sclerosis (MS), has consistently been shown to ameliorate disease progression and improve overall outcome. The effec[...]texto impreso
Fruehauf, H. ; Vavricka, S.R. ; Lutz, T.A. ; Gassmann, M. ; Wojtal, K.A. ; Erb, A. ; Maggiorini, M. ; Schwizer, W. ; Fried, M. ; Fox, M. ; Goetze, O. ; Greuter, T. | W.B. Saunders | 2020-12-14T16:06:23ZBackground & Aims: It is not clear how rapid ascent to a high altitude causes the gastrointestinal symptoms of acute mountain sickness (AMS). We assessed the incidence of endoscopic lesions in the upper gastrointestinal tract in healthy mountain[...]texto impreso
Koester-Hegmann, C. ; Bengoetxea, H. ; Kosenkov, D. ; Thiersch, M. ; Haider, T. ; Gassmann, M. ; Schneider Gasser, E.M. | Frontiers Media | 2019-12-06T21:02:56ZExposure to hypobaric hypoxia at high altitude (above 2500 m asl) causes cognitive impairment, mostly attributed to changes in brain perfusion and consequently neuronal death. Enriched environment and voluntary exercise has been shown to improve[...]texto impreso
Muckenthaler, M.U. ; Mairbäurl, H. ; Gassmann, M. | American Physiological Society | 2020-12-14T16:10:01ZResidents at high altitude cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here, we review available data [...]texto impreso
Ruetten, M. ; Steinmetz, H.W. ; Thiersch, M. ; Kik, M. ; Vaughan, L. ; Altamura, S. ; Muckenthaler, M.U. ; Gassmann, M. | Frontiers Media S.A. | 2020-12-14T16:10:08ZRestriction of nutrients to pathogens (nutritional immunity) is a critical innate immune response mechanism that operates when pathogens such as Mycobacterium tuberculosis have the potential to evade humoral immunity. Tuberculosis is of growing [...]texto impreso
Mamlouk, S. ; Kalucka, J. ; Singh, R.P. ; Franke, K. ; Muschter, A. ; Langer, A. ; Jakob, C. ; Gassmann, M. ; Baretton, G.B. ; Wielockx, B. | Wiley | 2020-06-10T18:11:35ZThe tumor microenvironment plays a pivotal role during cancer development and progression. The balance between suppressive and cytotoxic responses of the tumor immune microenvironment has been shown to have a direct effect on the final outcome i[...]texto impreso
Maxwell, P. ; Melendez-Rodríguez, F. ; Matchett, K.B. ; Aragones, J. ; Ben-Califa, N. ; Jaekel, H. ; Hengst, L. ; Lindner, H. ; Bernardini, A. ; Brockmeier, U. ; Fandrey, J. ; Grunert, F. ; Oster, H.S. ; Mittelman, M. ; El-Tanani, M. ; Thiersch, M. ; Schneider Gasser, E.M. ; Gassmann, M. ; Dangoor, D. ; Cuthbert, R.J. ; Irvine, A. ; Jordán, A. ; Lappin, T. ; Thompson, J. ; Neumann, D. | Wiley | 2019-02-22T14:54:59ZRecombinant human erythropoietin (rHuEPO) is an effective treatment for anaemia but concerns that it causes disease progression in cancer patients by activation of EPO receptors (EPOR) in tumour tissue have been controversial and have restricted[...]texto impreso
Residency at high altitude (HA) demands adaptation to challenging environmental conditions with hypobaric hypoxia being the most important one. Epidemiological and experimental data suggest that chronic exposure to HA reduces cancer mortality an[...]
