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Guzman, Jesus ; Castillo, Denis ; Ojeda, Manuel ; Sauvain, Michel | Instituto Nacional de Salud | 2019-12-06T20:57:43ZIn order to evaluate antimicrobial susceptibility and detect specific mutations in the 23S rRNA gene in Helicobacter pylori strains, a cross-sectional study was performed on 95 patients with dyspepsia treated in a private clinic in Lima. Antrum[...]texto impreso
Castillo, Denis ; Sauvain, Michel ; Rivaud, Marion ; Jullian, Valerie | Georg Thieme Verlag | 2020-06-10T18:12:14ZSeven benzo[c]phenanthridines, synthetic or isolated from Zanthoxylum rhoifolium root bark, were evaluated against Leishmania amazonensis axenic amastigotes. Five of them were considered leishmanicidal, with IC50 values ranging from 0.03 to 0.5[...]texto impreso
Cabanillas, Billy Joel ; Le Lamer, Anne-Cecile ; Olagnier, David ; Castillo, Denis ; Arevalo, Jorge ; Valadeau, Celine ; Coste, Agnes ; Pipy, Bernard ; Bourdy, Genevieve ; Sauvain, Michel ; Fabre, Nicolas | Elsevier | 2020-06-10T18:12:13ZETHNOPHARMACOLOGICAL RELEVANCE: Leaves and rhizomes of Renealmia thyrsoidea (Ruiz & Pav.) Poepp. & Endl. traditionally used in the Yanesha pharmacopoeia to treat skin infections such as leishmaniasis ulcers, or to reduce fever were chemically i[...]texto impreso
Jara, Marlene ; Berg, Maya ; Caljon, Guy ; de Muylder, Geraldine ; Cuypers, Bart ; Castillo, Denis ; Maes, Ilse ; Orozco, María Del Carmen ; Vanaerschot, Manu ; Dujardin, Jean-Claude ; Arevalo, Jorge | Public Library of Science | 2019-01-25T15:28:05ZIt was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana and Leishmania (Leishm[...]texto impreso
Vasquez-Ocmin, Pedro ; Haddad, Mohamed ; Gadea, Alice ; Jullian, Valerie ; Castillo, Denis ; Paloque, Lucie ; Cerapio, Juan Pablo ; Bourdy, Genevieve ; Sauvain, Michel | Taylor & Francis | 2019-01-25T15:02:14ZOne new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D ((1)H and (13)C [...]texto impreso
Trinel, Manon ; Jullian, Valerie ; Le Lamer, Anne-Cecile ; Mhamdi, Icram ; Mejia, Kember ; Castillo, Denis ; Cabanillas, Billy Joel ; Fabre, Nicolas | Wiley | 2018-11-30T22:50:36ZINTRODUCTION: The phytochemistry of the latex of Hura crepitans L. (Euphorbiaceae), a widespread tree in the Amazonian forest having many uses, is little known. Only huratoxin, a daphnane diterpene orthoester, has been described despite the high[...]
