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Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of

Sempou, Emily ; Biasini, Emiliano ; Pinzon-Olejua, Alejandro ; Harris, David-A. ; Malaga-Trillo, Edward | BMC | 2019-02-06T14:45:59Z

BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals cont[...]

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