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Hernández Torres, Gloria ; Enríquez Palacios, Ernesto ; Mecha Rodríguez, Miriam ; Feliú Martínez, Ana ; Rueda Zubiaurre, Ainoa ; Angelina Querencias, Alba ; Martín Cruz, Leticia ; Martín Fontecha, María del Mar ; Palomares, Oscar ; Guaza Rodríguez, Carmen ; Peña Cabrera, Eduardo ; López Rodríguez, María L. ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2018-05-07Serotonin (5-HT) modulates key aspects of the immune system. However, its precise function and the receptors involved in the observed effects have remained elusive. Among the different serotonin receptors, 5-HT1A plays an important role in the i[...]texto impreso
Martín Fontecha, María del Mar ; Angelina Querencias, Alba ; Rückert, Beate ; Rueda Zubiaurre, Ainoa ; Martín Cruz, Leticia ; Veen, Willem van de ; Akdis, Mübeccel ; Ortega Gutiérrez, Silvia ; López Rodríguez, María Luz ; Akdis, Cezmi A. ; Palomares, Oscar | American Chemical Society (ACS) | 2018-02-21The human endogenous cannabinoid system (ECS) regulates key physiological processes and alterations in its signaling pathways, and endocannabinoid levels are associated with diseases such as neurological and neuropsychiatric conditions, cancer, [...]texto impreso
Muñoz Úbeda, Mónica ; Tolosa Díaz, Andrés ; Bhattacharya, Santanu ; Junquera González, Elena ; Aicart Sospedra, Emilio ; Natale, Paolo ; López-Montero, Iván | American Chemical Society (ACS) | 2019Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins. The mitochondrial membran[...]texto impreso
Almendro Vedia, Víctor G. ; Natale, Paolo ; Chen, Su ; Monroy Muñoz, Francisco ; Rosilio, Véronique ; López-Montero, Iván | American Chemical Society (ACS) | 2017Since the first report of electroformed micrometersized liposomes in the 1980s, giant unilamellar vesicles (GUVs) have generated a lot of interest in the biophysical and biochemical communities. However, their penetration rate in high school or [...]texto impreso
Alonci, Giuseppe ; Fiorini, Federica ; Riva, Pietro ; Monroy Muñoz, Francisco ; López-Montero, Iván ; Perretta, Silvana ; De Cola, Luisa | American Chemical Society (ACS) | 2018Biocompatible soft materials have recently found applications in interventional endoscopy to facilitate resection of mucosal tumors. When neoplastic lesions are in organs that can be easily damaged by perforation, such as stomach, intestine, and[...]texto impreso
Montero de Hijes, Pablo ; Espinosa, Jorge R. ; Bianco, Valentino ; Sanz García, Eduardo ; Vega de las Heras, Carlos | American Chemical Society (ACS) | 2020In this work, we study by means of simulations of hard spheres the equilibrium between a spherical solid cluster and the fluid. In the NVT ensemble we observe stable/metastable clusters of the solid phase in equilibrium with the fluid, represent[...]texto impreso
Coelho, Joao Paulo ; Mayoral, María José ; Camacho, Luis ; Martín-Romero, María T. ; Tardajos Rodríguez, Gloria ; López-Montero, Iván ; Sanz García, Eduardo ; Ávila Brande, David ; Giner-Casares, Juan José ; Fernández, Gustavo ; Guerrero Martínez, Andrés | American Chemical Society (ACS) | 2017The ability to respond toward mechanical stimuli is a fundamental property of biological organisms at both the macroscopic and cellular levels, yet it has been considerably less observed in artificial supramolecular and colloidal homologues. An [...]texto impreso
Bravo-Osuna, Irene ; Vicario-de-la-Torre, Marta ; Andrés-Guerrero, Vanessa ; Sánchez-Nieves, Javier ; Guzmán-Navarro, Manuel ; de la Matad, F. Javier ; Gómez, Rafael ; de las Heras, Beatriz ; Argüesoh, Pablo ; Poncheli, Gilles ; Herrero-Vanrell, Rocio ; Molina-Martínez, Irene Teresa | American Chemical Society (ACS) | 2016-09-06Purpose: To determine the potential use of water-soluble anionic and cationic carbosilane dendrimers (Generations 1-3) as mucoadhesive polymers in eyedrop formulations. Methods: Cationic carbosilane dendrimers decorated with ammonium –NH3 + gro[...]texto impreso
Marín Ramos, Nagore Isasbel ; Balabasquer Peña, Moisés ; Ortega Nogales, Francisco Jesús ; Torrecillas, Iván R. ; Gil Ordóñez, Ana ; Marcos Ramiro, Beatriz ; Aguilar Garrido, Pedro ; Cushman, Ian ; Romero, Antonio ; Medrano, Francisco J. ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Philips, Mark R. ; Campillo, Mercedes ; Gallardo Delgado, Miguel ; Martín Fontecha, Mar ; López Rodríguez, María Luz ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2019-06-10Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the [...]
