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Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; González Álvaro, Isidoro ; Rodríguez Frade, José Miguel ; Mellado, Mario ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Nature Research | 2019-05-14Vasoactive Intestinal Peptide (VIP) is an important immunomodulator of CD4+ cells in normal and pathological conditions, which exerts its anti-infammatory and immunomodulatory actions through VPAC receptors, VPAC1 and VPAC2. Only a decrease in t[...]texto impreso
Ruiz-Alejos, Andrea ; Carrillo-Larco, Rodrigo M. ; Miranda, J. Jaime ; Anderson, Cheryl A. M. ; Gilman, Robert H. ; Smeeth, Liam ; Bernabé-Ortiz, Antonio | Nature Research | 2018-11-30T02:09:29ZThe aim of this study was to estimate the incidence of T2DM in three population groups: rural, rural-to-urban migrants and urban dwellers. Data from the PERU MIGRANT Study was analysed. The baseline assessment was conducted in 2007-2008 using a [...]texto impreso
Torres, A. ; Luque del Villar, Francisco Javier ; Tortajada, J. ; Arroyo de Dompablo, Elena | Nature Research | 2019Rechargeable lithium-ion batteries dominate the consumer electronics and electric vehicle markets. However, concerns on Li availability have prompted the development of alternative high energy density electrochemical energy storage systems. Rech[...]texto impreso
Asymmetric fows and drivers of herbaceous plant invasion success among Mediterranean-climate regions
Casado Hernández, Miguel Ángel ; Martín Forés, Irene ; Castro Parga, Isabel ; Miguel Garcinuño, José Manuel ; Acosta Gallo, Belén | Nature Research | 2018-11-15Understanding the mechanisms that support the arrival, establishment and spread of species over an introduced range is crucial in invasion ecology. We analysed the unintentionally introduced herbaceous species that are naturalised in the fve Med[...]texto impreso
Gomes, Cláudia ; Ruiz-Roldan, Lidia ; Mateu, Judit ; Ochoa, Theresa J. ; Ruiz, Joaquim | Nature Research | 2019-07-04T16:59:21ZDespite azithromycin being used in some countries to treat infections caused by Gram-negative pathogens, no resistance breakpoint for Escherichia coli exists. The aim of this study was to analyse the levels and mechanisms of azithromycin resista[...]texto impreso
Pinto, André Filipe Jorge ; Sánchez-Pastor, Nuria ; Callegari, Ivan ; Pracejus, Bernhard ; Scharf, Andreas | Nature Research | 2020Rutile, a common accessory mineral in a wide variety of rocks, is the most stable naturally occurring TiO2 polymorph. The relationship between its trace element composition and formation conditions has provided geoscientists with discriminant to[...]texto impreso
Gold, S.M. ; Köhler-Forsberg, O. ; Moss-Morris, R. ; Mehnert, A. ; Miranda, J.J. ; Bullinger, M. ; Steptoe, A. ; Whooley, M.A. ; Otte, C. | Nature Research | 2020-12-14T16:06:25ZDepression is one of the most common comorbidities of many chronic medical diseases including cancer and cardiovascular, metabolic, inflammatory and neurological disorders. Indeed, the prevalence of depression in these patient groups is often su[...]texto impreso
Prajapati, Surendra Kumar ; Borlon, Celine ; Rovira-Vallbona, Eduard ; Gruszczyk, Jakub ; Menant, Sebastien ; Tham, Wai-Hong ; Kattenberg, Johanna Helena ; Villasis, Elizabeth ; De Meulenaere, Katlijn ; Gamboa, Dionicia ; Vinetz, Joseph ; Fujita, Ricardo ; Xuan, Xa Nguyen ; Urbano Ferreira, Marcelo ; Nino, Carlos H. ; Patarroyo, Manuel A. ; Spanakos, Gregory ; Kestens, Luc ; Abbeele, Jan Van Den ; Rosanas-Urgell, Anna | Nature Research | 2019-07-04T16:59:26ZPlasmodium vivax parasites preferentially invade reticulocyte cells in a multistep process that is still poorly understood. In this study, we used ex vivo invasion assays and population genetic analyses to investigate the involvement of compleme[...]texto impreso
Lázaro Gorines, Rodrigo ; López Rodríguez, Juan Carlos ; Benedé, Sara ; González, Miguel ; Mayorga, Cristobalina ; Vogel, Lothar ; Martínez del Pozo, Álvaro ; Lacadena, Javier ; Villalba, Mayte | Nature Research | 2020-07-23Immunotoxins appear as promising therapeutic molecules, alternative to allergen-specifcimmunotherapy. In this work, we achieved the development of a protein chimera able to promote specifc cell death on efector cells involved in the allergic rea[...]texto impreso
José Fernández, José ; Escayo, Joaquin ; Hu, Zhongbo ; Camacho, A.G. ; Samsonov, Sergey V. ; Prieto, Juan F. ; Tiampo, Kristy F. ; Palano, Mimmo ; Mallorquí, Jordi J. ; Ancochea Soto, Eumenio | Nature Research | 2021La Palma island is one of the highest potential risks in the volcanic archipelago of the Canaries and therefore it is important to carry out an in-depth study to define its state of unrest. This has been accomplished through the use of satellite[...]texto impreso
Quinto-Sanchez, Mirsha ; Muñoz-Muñoz, Francesc ; Gomez-Valdes, Jorge ; Cintas, Celia ; Navarro, Pablo ; Cerqueira, Caio Cesar Silva de ; Paschetta, Carolina ; de Azevedo, Soledad ; Ramallo, Virginia ; Acuna-Alonzo, Victor ; Adhikari, Kaustubh ; Fuentes-Guajardo, Macarena ; Hunemeier, Tabita ; Everardo, Paola ; de Avila, Francisco ; Jaramillo, Claudia ; Arias, Williams ; Gallo, Carla ; Poletti, Giovani ; Bedoya, Gabriel ; Bortolini, Maria Catira ; Canizales-Quinteros, Samuel ; Rothhammer, Francisco ; Rosique, Javier ; Ruiz-Linares, Andrés ; González-José, Rolando | Nature Research | 2018-11-30T03:10:44ZFacial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simulta[...]texto impreso
LaMonte, G.M. ; Orjuela-Sanchez, P. ; Calla, J. ; Wang, L.T. ; Li, S. ; Swann, J. ; Cowell, A.N. ; Zou, B.Y. ; Abdel-Haleem Mohamed, A.M. ; Villa Galarce, Z.H. ; Moreno, M. ; Tong Rios, C. ; Vinetz, J.M. ; Lewis, N. ; Winzeler, E.A. | Nature Research | 2019-12-06T21:04:40ZThe exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin[...]texto impreso
LaMonte, Gregory M. ; Orjuela-Sanchez, Pamela ; Calla, Jaeson ; Wang, Lawrence T. ; Li, Shangzhong ; Swann, Justine ; Cowell, Annie N. ; Zou, Bing Yu ; Abdel-Haleem Mohamed, Alyaa M. ; Villa Galarce, Zaira Hellen ; Moreno, Marta ; Tong Rios, Carlos ; Vinetz, Joseph M. ; Lewis, Nathan ; Winzeler, Elizabeth A. | Nature Research | 2019-07-04T16:59:30ZThe exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin[...]texto impreso
Martínez-García, Marina ; Fernández-Jiménez, Nadia ; Santos Coloma, Juan L. ; Pradillo Orellana, Mónica | Nature Research | 2020-06-01Rubylation is a conserved regulatory pathway similar to ubiquitination and essential in the response to the plant hormone auxin. In Arabidopsis thaliana, AUXIN RESISTANT1 (AXR1) functions as the E1-ligase in the rubylation pathway. The gene AXR1[...]texto impreso
Bernabé-Ortiz, Antonio ; Sal Y Rosas, Víctor G. ; Ponce-Lucero, Vilarmina ; Cárdenas, María K. ; Carrillo-Larco, Rodrigo M. ; Diez-Canseco, Francisco ; Pesantes, M. Amalia ; Sacksteder, Katherine A. ; Gilman, Robert H. ; Miranda, J. Jaime | Nature Research | 2020-07-14T00:00:57ZReplacement of regular salt with potassium-enriched substitutes reduces blood pressure in controlled situations, mainly among people with hypertension. We report on a population-wide implementation of this strategy in a stepped-wedge cluster ran[...]
