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Berg, Stefan ; García Pelayo, M Carmen ; Müller, Borna ; Hailu, Elena ; Asiimwe, Benon ; Kremer, Kristin ; Dale, James ; Boniotti, M Beatrice ; Rodriguez, Sabrina ; Hilty, Markus ; Rigouts, Leen ; Firdessa, Rebuma ; Machado, Adelina ; Mucavele, Custodia ; Ngandolo, Bongo Nare Richard ; Bruchfeld, Judith ; Boschiroli, Laura ; Müller, Annélle ; Sahraoui, Naima ; Pacciarini, Maria ; Cadmus, Simeon ; Joloba, Moses ; van Soolingen, Dick ; Michel, Anita L ; Djønne, Berit ; Aranaz Martín, Alicia ; Zinsstag, Jakob ; van Helden, Paul ; Portaels, Françoise ; Kazwala, Rudovick ; Källenius, Gunilla ; Hewinson, R Glyn ; Aseffa, Abraham ; Gordon, Stephen V ; Smith, Noel H | American Society for Microbiology | 2011-02We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M. bovis. Af[...]texto impreso
Travis, Emma R ; Gaze, William H ; Pontiroli, Alessandra ; Sweeney, Francis P ; Porter, David ; Mason, Sam ; Keeling, Matthew J C ; Jones, Rebecca M ; Sawyer, Jason ; Aranaz Martín, Alicia ; Castellanos Rizaldos, Elena ; Cork, Jennifer ; Delahay, Richard J ; Wilson, Gavin J ; Hewinson, R Glyn ; Courtenay, Orin ; Wellington, Elizabeth M H | Public Library Science | 2011Advances in the diagnosis of Mycobacterium bovis infection in wildlife hosts may benefit the development of sustainable approaches to the management of bovine tuberculosis in cattle. In the present study, three laboratories from two different co[...]texto impreso
Beltrán Beck, Beatriz ; Romero Martínez, Beatriz ; Sevilla, Iker A ; Barasona, Jose A ; Garrido, Joseba M ; González-Barrio, David ; Díez Delgado, Iratxe ; Minguijón, Esmeralda ; Casal, Carmen ; Vicente, Joaquín ; Gortazar, Christian ; Aranaz Martín, Alicia | American Society for Microbiology | 2014-01Wildlife vaccination is increasingly being considered as an option for tuberculosis control. We combined data from laboratory trials and an ongoing field trial to assess the risk of an oral Mycobacterium bovis BCG vaccine and a prototype heat-in[...]texto impreso
Castellanos, Elena ; Aranaz Martín, Alicia ; Gould, Katherine A ; Linedale, Richard ; Stevenson, Karen ; Álvarez Sánchez, Julio ; Domínguez Rodríguez, Lucas ; Juan Ferré, Lucia de ; Hinds, Jason ; Bull, Tim J | American Society for Microbiology | 2009-02Mycobacterium avium subsp. paratuberculosis is an important animal pathogen widely disseminated in the environment that has also been associated with Crohn's disease in humans. Three M. avium subsp. paratuberculosis genomotypes are recognized, b[...]texto impreso
Álvarez Sánchez, Julio ; Gómez García, Ignacio ; Aranaz Martín, Alicia ; Bezos Garrido, Javier ; Romero Martínez, Beatriz ; Juan Ferré, Lucia de ; Mateos García, Ana ; Gómez Mampaso, Enrique ; Domínguez Rodríguez, Lucas | American Society for Microbiology | 2008-04Isolation of Mycobacterium avium complex (MAC) organisms from clinical samples may occur in patients without clinical disease, making the interpretation of results difficult. The clinical relevance of MAC isolates from different types of clinica[...]texto impreso
Rodriguez Campos, Sabrina ; Aranaz Martín, Alicia ; Juan Ferré, Lucia de ; Sáez Llorente, José Luis ; Romero Martínez, Beatriz ; Bezos Garrido, Javier ; Jiménez, Antonio ; Mateos García, Ana ; Domínguez Rodríguez, Lucas | American Society for Microbiology | 2011-09This study describes the attempt to trace the first Mycobacterium bovis outbreak in alpacas (Lama pacos) in Spain by spoligotyping and variable-number tandem-repeat (VNTR) analysis. Due to high genotype diversity, no matching source was identifi[...]texto impreso
Gortazar, Christian ; Beltrán-Beck, Beatriz ; Garrido, Joseba M ; Aranaz Martín, Alicia ; Sevilla, Iker A ; Boadella, Mariana ; Lyashchenko, Konstantin P ; Galindo, Ruth C ; Montoro, Vidal ; Domínguez Rodríguez, Lucas ; Juste, Ramón ; De la Fuente, Jose | BioMedCentral | 2014-04-26BACKGROUND Field vaccination trials with Mycobacterium bovis BCG, an attenuated mutant of M. bovis, are ongoing in Spain, where the Eurasian wild boar (Sus scrofa) is regarded as the main driver of animal tuberculosis (TB). The oral baiting str[...]texto impreso
Beltrán-Beck, Beatriz ; De la Fuente, Jose ; Garrido, Joseba M ; Aranaz Martín, Alicia ; Sevilla, Iker ; Villar, Margarita ; Boadella, Mariana ; Galindo, Ruth C ; Pérez de la Lastra, José M ; Moreno Cid, Juan A ; Fernández de Mera, Isabel G ; Alberdi, Pilar ; Santos, Gracia ; Ballesteros, Cristina ; Lyashchenko, Konstantin P ; Minguijón, Esmeralda ; Romero Martínez, Beatriz ; Juan Ferré, Lucia de ; Domínguez Rodríguez, Lucas ; Juste, Ramón ; Gortazar, Christian | Public Library Science | 2014Tuberculosis (TB) remains a pandemic affecting billions of people worldwide, thus stressing the need for new vaccines. Defining the correlates of vaccine protection is essential to achieve this goal. In this study, we used the wild boar model fo[...]texto impreso
Dieli, Francesco ; Garrido, Joseba M. ; Sevilla, Iker A. ; Beltrán-Beck, Beatriz ; Minguijón, Esmeralda ; Ballesteros, Cristina ; Galindo, Ruth C. ; Boadella, Mariana ; Lyashchenko, Konstantin P. ; Romero Martínez, Beatriz ; Geijo, Maria Victoria ; Ruiz Fons, Francisco ; Aranaz Martín, Alicia ; Juste, Ramón A. ; Vicente, Joaquín ; De la Fuente, Jose ; Gortazar, Christian | 2011Tuberculosis (TB) caused by Mycobacterium bovis and closely related members of the Mycobacterium tuberculosis complex continues to affect humans and animals worldwide and its control requires vaccination of wildlife reservoir species such as Eur[...]texto impreso
Castellanos, Elena ; Aranaz Martín, Alicia ; De Buck, Jeroen | American Society for Microbiology | 2010-04High-resolution melt (HRM) analysis can identify sequence polymorphisms by comparing the melting curves of amplicons generated by real-time PCR amplification. We describe the application of this technique to identify Mycobacterium avium subspeci[...]texto impreso
Romero Martínez, Beatriz ; Aranaz Martín, Alicia ; Bezos Garrido, Javier ; Álvarez Sánchez, Julio ; Juan Ferré, Lucia de ; Mateos García, Ana ; Gómez Mampaso, Enrique ; Domínguez Rodríguez, Lucas | American Society for Microbiology | 2008-02Mycobacterium bovis is the etiological agent of tuberculosis in domestic and wild animals. Its involvement as a human pathogen has been highlighted again with the recent descriptions of transmission through dairy products (18), reactivation or p[...]texto impreso
Castellanos, Elena ; Aranaz Martín, Alicia ; Juan Ferré, Lucia de ; Álvarez Sánchez, Julio ; Rodriguez, Sabrina ; Romero Martínez, Beatriz ; Bezos Garrido, Javier ; Stevenson, Karen ; Mateos García, Ana ; Domínguez Rodríguez, Lucas | American Society for Microbiology | 2009-07Insertion sequence IS900 is used as a target for the identification of Mycobacterium avium subsp. paratuberculosis. Previous reports have revealed single nucleotide polymorphisms within IS900. This study, which analyzed the IS900 sequences of a [...]texto impreso
Rodriguez Campos, Sabrina ; Navarro, Yurena ; Romero Martínez, Beatriz ; Juan Ferré, Lucia de ; Bezos Garrido, Javier ; Mateos García, Ana ; Golby, Paul ; Smith, Noel H ; Hewinson, Glyn R ; Domínguez Rodríguez, Lucas ; García de Viedma, Darío ; Aranaz Martín, Alicia | 2013-11Mycobacterium bovis populations in countries with persistent bovine tuberculosis usually show a prevalent spoligotype with a wide geographical distribution. This study applied mycobacterial interspersed repetitive-unit-variable-number tandem-rep[...]
