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Francisco Martínez, Patricia de ; Amaro Torres, Francisco ; Martín González, Ana María ; Gutiérrez Fernández, Juan Carlos | University of Geneva | 2018-10-23Metallothioneins (MT) are multi-stress proteins mainly involved in metal detoxification. MT gene expression is normally induced by a broad variety of stimulus and its gene expression regulation mainly occurs at a transcriptional level. Conserved[...]texto impreso
Francisco Martínez, Patricia de ; Martín González, Ana María ; Turkewitz, Aaron P. ; Gutiérrez Fernández, Juan Carlos | PLOS | 2017Metallothioneins (MT) constitute a superfamily of small cytosolic proteins that are able to bind metal cations through numerous cysteine (Cys) residues. Like other organisms the ciliate Tetrahymena thermophila presents several MT isoforms, which[...]texto impreso
Algunos metales son esenciales en múltiples procesos biológicos pero otros, sin embargo,se incluyen entre los contaminantes más abundantes y persistentes del planeta, llegando a serconsiderados como prioritarios. Los seres vivos han desarrollado[...]texto impreso
Romero Sobrino, Iván ; Francisco Martínez, Patricia de ; Gutiérrez, Juan Carlos ; Martín-González, Ana María | Elsevier | 2019-06-25Selenium is an essential micronutrient but at high concentrations can produce severe cytotoxicity and genomic damage. We have evaluated the cytotoxicity, ultrastructural and mitochondrial alterations of the two main selenium inorganic species; s[...]texto impreso
Gutiérrez Fernández, Juan Carlos ; Francisco Martínez, Patricia de ; Amaro Torres, Francisco ; Díaz, Silvia ; Martín González, Ana María | Elsevier | 2018-10-16In the present review, we discussed the concept of metallothionein (MT) and analyzed the structural and functional diversity of microbial MTs, grouping them into three main groups; bacteria, fungi, and protists. Structural diversity is analyzed [...]texto impreso
Cubas-Gaona, Liliana L. ; Francisco Martínez, Patricia de ; Martín-González, Ana María ; Gutiérrez Fernández, Juan Carlos | MDPI | 2020-07-05In the present work, an extensive analysis of the putative glutathione peroxidases (GPx) of the eukaryotic microorganism model Tetrahymena thermophila is carried out. A comparative analysis with GPx present in other Tetrahymena species and other[...]texto impreso
Francisco Martínez, Patricia de ; Melgar, Laura María ; Díaz del Toro, Silvia ; Martín González, Ana María ; Gutiérrez Fernández, Juan Carlos | BioMed Central | 2016-05-16Background: Ciliate metallothioneins (MTs) are included in family 7 of the MT superfamily. This family has been divided into two main subfamilies: 7a or CdMTs and 7b or CuMTs. All ciliate MTs reported have been isolated from different Tetrahymen[...]texto impreso
Díaz, Silvia ; Francisco Martínez, Patricia de ; Olsson, Sanna ; Aguilera, Ángeles ; González-Toril, Elena ; Martín González, Ana María | MDPI | 2020-03-03The cytotoxicity of cadmium (Cd), arsenate (As(V)), and arsenite (As(III)) on a strain of Chlamydomonas acidophila, isolated from the Rio Tinto, an acidic environment containing high metal(l)oid concentrations, was analyzed. We used a broad arra[...]
