Información del autor
Documentos disponibles escritos por este autor (13)
Añadir el resultado a su cesta Hacer una sugerencia Refinar búsqueda
texto impreso
Esteban Fernández, Diego ; Verdaguer, J.M. ; Ramírez, R. ; Palacios Corvillo, María A. ; Gómez Gómez, M. Milagros | Oxford Academic | 2008-03Antitumoral Pt-containing drugs present side effects like nephrotoxicity and ototoxicity. Several systematic experiments have been carried out with Wistar rats treated with cisplatin, carboplatin, and oxaliplatin to study Pt-drugs accumulation a[...]texto impreso
Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Cañas, Benito ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2010Pt-containing drugs are nowadays essential components in cancer chemotherapy. However, drug resistance and side effects limit the efficiency of the treatments. In order to improve the response to Pt-based drugs, different administration strategi[...]texto impreso
Esteban Fernández, Diego ; El-Khatib, Ahmed H. ; Moraleja San José, Irene ; Gómez Gómez, M.Milagros ; Linscheid, Michael W. | ACS | 2014-12-22Molecular mass spectrometry has been applied to simultaneously obtain molecular and elemental information from metal-containing species. Energy tuning of the higher-energy collision dissociation (HCD) fragmentation cell allows the controlled pro[...]texto impreso
Ramírez Camacho, R. ; Esteban Fernández, Diego ; Verdaguer, J.M. ; Gómez Gómez, M. Milagros ; Trinidad, A. ; García Berrocal, J.R. ; Palacios Corvillo, M. Antonia | Taylor and Francis | 2008Conclusion. Inductively coupled plasma mass spectrometry (ICP-MS) can be applied to organic tissues obtained from experimental animals. Hearing loss does not correlate with the platinum (Pt) concentration found in the inner ear. Drug structure a[...]texto impreso
El Platino (Pt) es un elemento químico de número atómico 78 y que pertenece al grupo 10 de la tabla periódica. Su configuración electrónica es [Xe] 4f14 5d9 6s1. Se trata de un metal de transición blanco grisáceo, precioso, pesado, maleable y dú[...]texto impreso
Aboulmagd, Sarah ; Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Neumann, Boris ; El-Khatib, A.H. ; Lázaro, Alberto ; Tejedor, Alberto ; Gómez Gómez, M.Milagros ; Linscheid, Michael W. | ACS | 2017The quest for internal standards useful in MALDI imaging studies goes on to get not only lateral distribution but also reliable relative quantitative information. We developed a method based on application of matrix and dual internal standards t[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Giesen, Charlotte ; Lehmann, Karola ; Lázaro, Alberto ; Tejedor, Alberto ; Scheler, Christian ; Cañas Montalvo, Benito ; Jakubowski, Norbert ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | RSC | 2012A method for the analysis of Pt–protein complexes in biological samples, previously subjected to cisplatin treatment, has been developed. Proteins were separated by gel electrophoresis, and those bound to Pt were detected with high sensitivity b[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Lázaro, Alberto ; Aboulmagd, Sarah ; Humanes, Blanca ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | American Society for Biochemistry and Molecular Biology Inc. | 2018-07Nephrotoxicity is a major limitation to cisplatin antitumor therapies. Cilastatin, an inhibitor of renal dehydropeptidase-I, was recently proposed as a promising nephroprotector against cisplatin toxicity, preventing apoptotic cell death. In thi[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Lázaro, Alberto ; Humanes, Blanca ; Aboulmagd, Sarah ; Tejedor, Alberto ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | Elsevier | 2017Imaging techniques for mapping molecular distributions in tissue sections can reveal valuable information on biomolecules involved in relevant biochemical processes. A method has been developed for comprehensive, reproducible and sensitive lipid[...]texto impreso
Amrán, Donna ; Sancho, Patricia ; Fernández, Carlos ; Esteban Fernández, Diego ; Ramos, Adrian M. ; Blas, Elena de ; Gómez Gómez, M.Milagros ; Palacios Corvillo, María A. ; Aller, Patricio | Elsevier | 2005It has been reported that inhibition of extracellular signal-regulated protein kinases (ERKs) attenuates the toxicity cisplatin (cisplatinum (II)-diammine dichloride) in some cell types. This response was here investigated using human myeloid le[...]texto impreso
Moraleja San José, Irene ; Esteban Fernández, Diego ; Lázaro, Alberto ; Humanes, Blanca ; Neumann, Boris ; Tejedor, Alberto ; Mena, María Luz ; Jakubowski, Norbert ; Gómez Gómez, M.Milagros | Springer | 2016The study of the distribution of the cytostatic drugs cisplatin, carboplatin, and oxaliplatin along the kidney may help to understand their different nephrotoxic behavior. Laser ablation inductively coupled plasma mass spectrometry (LAICP-MS) al[...]texto impreso
SEC-ICP-MS and ESI-MS as tools to study the interaction between cisplatin and cytosolic biomolecules
Esteban Fernández, Diego ; Cañas, Benito ; Pizarro, I. ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2007Most of cisplatin’s citotoxic properties are due to the interaction of the drug with DNA. However, other biological molecules present in the cell cytosol, such as MT (metallothionein) and GSH (glutathione), are potential targets for cisplatin an[...]texto impreso
Esteban Fernández, Diego ; Gómez Gómez, M.Milagros ; Cañas, Benito ; Verdaguer, J.M. ; Ramírez, R. ; Palacios Corvillo, M.Antonia | Elsevier | 2007Chemical compounds containing platinum have been employed since 1978 as drugs to beat certain type of tumours. Nevertheless, besides of their exceptional antitumoral properties, these drugs also have important deleterious side effects, such as, [...]
