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Camano, Sonia ; Lázaro, Alberto ; Moreno Gordaliza, Estefanía ; Torres, A.M. ; Lucas, Carmen de ; Humanes, Blanca ; Lázaro, José A. ; Gómez Gómez, M.Milagros ; Bosca, Lisardo ; Tejedor, Alberto | American Society for Pharmacology and Experimental Therapeutics | 2010A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated the protective effect of cilastatin on cisplatininduced injury to renal proximal tubular cells. Cilastatin is a spec[...]texto impreso
Humanes, Blanca ; Lázaro, Alberto ; Camano, Sonia ; Moreno Gordaliza, Estefanía ; Lázaro, José A. ; Blanco Codesido, Montserrat ; Lara, José M. ; Ortiz, Alberto ; Gómez Gómez, M.Milagros ; Martín Vasallo, Pablo ; Tejedor, Alberto | International Society of Nephrology | 2012Cisplatin is an anticancer agent marred by nephrotoxicity; however, limiting this adverse effect may allow the use of higher doses to improve its efficacy. Cilastatin, a small molecule inhibitor of renal dehydropeptidase I, prevents proximal tub[...]texto impreso
Aboulmagd, Sarah ; Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Neumann, Boris ; El-Khatib, A.H. ; Lázaro, Alberto ; Tejedor, Alberto ; Gómez Gómez, M.Milagros ; Linscheid, Michael W. | ACS | 2017The quest for internal standards useful in MALDI imaging studies goes on to get not only lateral distribution but also reliable relative quantitative information. We developed a method based on application of matrix and dual internal standards t[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Giesen, Charlotte ; Lehmann, Karola ; Lázaro, Alberto ; Tejedor, Alberto ; Scheler, Christian ; Cañas Montalvo, Benito ; Jakubowski, Norbert ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | RSC | 2012A method for the analysis of Pt–protein complexes in biological samples, previously subjected to cisplatin treatment, has been developed. Proteins were separated by gel electrophoresis, and those bound to Pt were detected with high sensitivity b[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Lázaro, Alberto ; Aboulmagd, Sarah ; Humanes, Blanca ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | American Society for Biochemistry and Molecular Biology Inc. | 2018-07Nephrotoxicity is a major limitation to cisplatin antitumor therapies. Cilastatin, an inhibitor of renal dehydropeptidase-I, was recently proposed as a promising nephroprotector against cisplatin toxicity, preventing apoptotic cell death. In thi[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Lázaro, Alberto ; Humanes, Blanca ; Aboulmagd, Sarah ; Tejedor, Alberto ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | Elsevier | 2017Imaging techniques for mapping molecular distributions in tissue sections can reveal valuable information on biomolecules involved in relevant biochemical processes. A method has been developed for comprehensive, reproducible and sensitive lipid[...]texto impreso
Moraleja San José, Irene ; Esteban Fernández, Diego ; Lázaro, Alberto ; Humanes, Blanca ; Neumann, Boris ; Tejedor, Alberto ; Mena, María Luz ; Jakubowski, Norbert ; Gómez Gómez, M.Milagros | Springer | 2016The study of the distribution of the cytostatic drugs cisplatin, carboplatin, and oxaliplatin along the kidney may help to understand their different nephrotoxic behavior. Laser ablation inductively coupled plasma mass spectrometry (LAICP-MS) al[...]
