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Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1

Lorente Pérez, Mar ; García-Casas, Ana ; Salvador, Nélida ; Martínez-López, Angélica ; Gabicagogeascoa, Estíbaliz ; Velasco, Guillermo ; López-Palomar, Lucía ; Castillo-Lluva, Sonia | The Company of Biologists Ltd | 2019-10-02

Post-translational modifications directly control protein activity and thus, they represent an important means to regulate the responses of cells to different stimuli. Protein SUMOylation has recently been recognised as one such modification and[...]

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Lung Surfactant Lipids Provide Immune Protection Against Haemophilus influenzae Respiratory Infection

García-Fojeda, Belén ; González-Carnicero, Zoe ; Lorenzo Avilés, Alba de ; Minutti, Carlos M. ; Tapia, Lidia de ; Euba, Begoña ; Iglesias-Ceacero, Alba ; Castillo-Lluva, Sonia ; Garmendia, Junkal ; Casals Carro, Cristina | Frontiers Media | 2019-03-18

Non-typeable Haemophilus influenzae (NTHi) causes persistent respiratory infections in patients with chronic obstructive pulmonary disease (COPD), probably linked to its capacity to invade and reside within pneumocytes. In the alveolar fluid, NT[...]

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