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Ruwisch, Jannik ; Sehlmeyer, Kirsten ; Roldán López, Nuria ; García Álvarez, Begoña ; Pérez-Gil, Jesús ; Weaver, Timothy E. ; Ochs, Matthias ; Knudsen, Lars ; López-Rodríguez, Elena | American Thoracic Society | 2020-01-10Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling in aging mice and alveolar l[...]texto impreso
Roldán López, Nuria ; Pérez Gil, Jesús ; Morrow, Michael R. ; García Álvarez, Begoña | Elsevier | 2017-08-22Lung surfactant (LS) is an essential system supporting the respiratory function. Cholesterol can be deleterious for LS function, a condition that is reversed by the presence of the lipopeptide SP-C. In this work, the structure of LS-mimicking me[...]texto impreso
Roldán López, Nuria ; Nyholm, Thomas K. M. ; Slotte, J. Peter ; Pérez Gil, Jesús ; García Álvarez, Begoña | BIOPHYSICAL SOCIETY | 2016-10-18To allow breathing and prevent alveolar collapse, lung surfactant (LS) develops a complex membranous system at the respiratory surface. LS is defined by a specific protein and lipid composition, including saturated and unsaturated phospholipid s[...]texto impreso
Roldán López, Nuria ; Goormaghtigh, Erik ; Pérez Gil, Jesús ; García Álvarez, Begoña | Elsevier | 2015-01Surfactant protein C (SP-C) has been regarded as the most specific protein linked to development of mammalian lungs, and great efforts have been done to understand its structure–function relationships. Previous evidence has outlined the importan[...]texto impreso
López-Rodríguez, Elena ; Roldán López, Nuria ; García-Álvarez, Begoña ; Pérez-Gil, Jesús | American Society for Biochemistry and Molecular Biology | 2019-02Traditionally, thin layer chromatography (TLC) has been used for the analysis of lipids isolated from membrane complexes. Here, we describe a method based on the combination of TLC and SDS-polyacrylamide gel electrophoresis (SDS-PAGE) for the qu[...]texto impreso
La función respiratoria depende del establecimiento de una interfase aire-líquido que tiene lugar en los alveolos pulmonares. La estabilización de dicha interfase requiere la presencia de un complejo lipoproteico que es sintetizado y secretado p[...]
