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González Rubio, Sergio ; Montero Pastor, Nuria ; García, Carolina ; Almendro Vedia, Víctor G. ; Ferrer, Irene ; Natale, Paolo ; Paz-Ares, Luis ; Lillo, M. Pilar ; López-Montero, Iván | Frontiers Media | 2018-11Cancer cell mitochondria represent an attractive target for oncological treatment as they have unique hallmarks that differ from their healthy counterparts, as the presence of a stronger membrane potential that can be exploited to specifically a[...]texto impreso
Muñoz Úbeda, Mónica ; Tolosa Díaz, Andrés ; Bhattacharya, Santanu ; Junquera González, Elena ; Aicart Sospedra, Emilio ; Natale, Paolo ; López-Montero, Iván | American Chemical Society (ACS) | 2019Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins. The mitochondrial membran[...]texto impreso
Gutiérrez-Sanz, Óscar ; Natale, Paolo ; Márquez, Ileana ; Marques, Marta C. ; Zacarias, Sonia ; Pita, Marcos ; Pereira, Inês A. C. ; López-Montero, Iván ; De Lacey, Antonio L. ; Vélez, Marisela | Wiley-VCH Verlag GmbH & Co. KGaA. | 2016ATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modif[...]texto impreso
Almendro Vedia, Víctor G. ; Natale, Paolo ; Chen, Su ; Monroy Muñoz, Francisco ; Rosilio, Véronique ; López-Montero, Iván | American Chemical Society (ACS) | 2017Since the first report of electroformed micrometersized liposomes in the 1980s, giant unilamellar vesicles (GUVs) have generated a lot of interest in the biophysical and biochemical communities. However, their penetration rate in high school or [...]texto impreso
de la Fuente Herreruela, Diego ; Monnappa, Ajay K. ; Muñoz Úbeda, Mónica ; Morallón Piña, Aarón ; Enciso Rodríguez, Eduardo ; Sánchez Martín, Luis ; Giusti, Fabrice ; Natale, Paolo ; López-Montero, Iván | BMC | 2019Background: The design of efcient drug delivery vectors requires versatile formulations able to simultaneously direct a multitude of molecular targets and to bypass the endosomal recycling pathway of cells. Liposomal-based vectors need the decor[...]texto impreso
Encinar, Mario ; Casado, Santiago ; Calzado-Martín, Alicia ; Natale, Paolo ; San Paulo, Álvaro ; Calleja, Montserrat ; Vélez, Marisela ; Monroy Muñoz, Francisco ; López-Montero, Iván | Elsevier | 2017Erythrocyte membranes have been particularly useful as a model for studies of membrane structure and mechanics. Native erythroid membranes can be electroformed as giant unilamellar vesicles (eGUVs). In the presence of ATP, the erythroid membrane[...]texto impreso
Almendro-Vedia, Víctor G. ; Natale, Paolo ; Mell, Michael ; Bonneau, Stephanie ; Monroy Muñoz, Francisco ; Joubert, Frederic ; López-Montero, Iván | National Academy of Sciences | 2017ATP synthase is a rotating membrane protein that synthesizes ATP through proton-pumping activity across the membrane. To unveil the mechanical impact of this molecular active pump on the bending properties of its lipid environment, we have funct[...]texto impreso
Plaza-GA, Ismael ; Manzaneda González, Vanesa ; Kisovec, Matic ; Almendro Vedia, Víctor ; Muñoz Úbeda, Mónica ; Anderluh, Gregor ; Guerrero Martínez, Andrés ; Natale, Paolo ; López-Montero, Iván | BMC | 2019Background: A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In nature, the bacterial pa[...]texto impreso
de la Fuente Herreruela, Diego ; Gónzalez Charro, Vicente ; Almendro Vedia, Víctor G. ; Morán, María ; Martín, Miguel Ángel ; Lillo, M. Pilar ; Natale, Paolo ; López-Montero, Iván | Elsevier | 2017Mitochondria are essential for the production and maintenance of ATP in the eukaryotic cell. To image and monitor intracellular ATP level without cell breakage, biological and chemical sensors were developed in the last years. Here, we have inte[...]texto impreso
Almendro Vedia, Víctor G. ; García, Carolina ; Ahijado Guzmán, Rubén ; de la Fuente Herreruela, Diego ; Muñoz Úbeda, Mónica ; Natale, Paolo ; Viñas, Montserrat H. ; Albuquerque, Rodrigo Queiroz ; Guerrero Martínez, Andrés ; Monroy, Francisco ; Lillo, M. Pilar ; López-Montero, Iván | Elsevier | 2018Background: The fluorescent dye 10-N-nonyl acridine orange (NAO) is widely used as a mitochondrial marker. NAO was reported to have cytotoxic effects in cultured eukaryotic cells when incubated at high concentrations. Although the biochemical re[...]texto impreso
Catapano, Elisa R. ; Natale, Paolo ; Monroy Muñoz, Francisco ; López-Montero, Iván | Elsevier | 2017Whereas most of lipids have viscous properties and they do not have significant elastic features, ceramides behave as very rigid solid assemblies, displaying viscoelastic behaviour at physiological temperatures. The present review addresses the [...]texto impreso
Catapano, Elisa R. ; Lillo, M. P. ; García Rodríguez, C. ; Natale, Paolo ; Langevin, D. ; Monroy Muñoz, Francisco ; López-Montero, Iván | American Chemical Society | 2015Ceramides have unique biophysical properties. Their high melting temperature and their ability to form lateral domains have converted ceramides into the paradigm of rigid lipids. Here, using shear surface rheology of egg-ceramide Langmuir monola[...]
