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Daza, Rafael ; González Bermúdez, Blanca ; Cruces, Julia ; Fuente del Rey, Mónica de la ; Plaza, Gustavo R. ; Arroyo Hernández, María ; Elices, Manuel ; Pérez Rigueiro, José ; Guinea, Gustavo V. | Elsevier | 2019-04-08A comparative analysis of T-lymphocyte mechanical data obtained from Micropipette Aspiration (MPA) andAtomic Force Microscopy (AFM) is presented. Results obtained byfitting the experimental data to simple Hertzand Theret models led to non-Gaussi[...]texto impreso
Martínez de Toda Cabeza, Irene ; Maté, Ianire ; Vida, Carmen ; Cruces, Julia ; Fuente del Rey, Mónica de la | Aging | 2016Chronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the bi[...]texto impreso
Esteban Manzanares, Gustavo ; González Bermúdez, Blanca ; Cruces, Julia ; Fuente del Rey, Mónica de la ; Li, Qingxuan ; Guinea, Gustavo V. ; Pérez Rigueiro, José ; Elices, Manuel ; Plaza, Gustavo R. | Springer Link | 2017-05Mechanical deformability of cells is an important property for their function and development, as well as a useful marker of cell state. The classical technique of micropipette aspiration allows single-cell studies and we provide here a method t[...]texto impreso
The homeostatic systems, such as the nervous and immune systems, show deterioration in aging as a consequence of the agerelated oxidative-infammatory stress establishment. The supplementation with fermented milk containing probiotic bacteria cou[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Iriarte, Idoia ; Hernández Sánchez, Catalina ; Pablo, Flora de ; Fuente del Rey, Mónica de la | Elsevier | 2017-02Introducción: La salud depende del buen funcionamiento de los sistemas homeostáticos (el nervioso, endocrino e inmunitario) y de la adecuada comunicación entre ellos. Se ha comprobado que el estado funcional y redox del sistema inmunitario es un[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, Noemí ; Vara Ameigeiras, Elena ; Fuente del Rey, Mónica de la | MDPI | 2019-02-12Oxidative and inflammatory stresses are closely related processes, which contribute to age-associated impairments that affect the regulatory systems such as the immune system and its immunosenescence. Therefore, the aim of this work was to confi[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, N. ; Hernández-Sánchez, C. ; Fuente del Rey, Mónica de la | Elsevier | 2018Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. In this context, there is an age-related alteration of the physiological response to acute stress, which is modula[...]texto impreso
Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Cruces, Julia ; Garrido Tarrio, Antonio ; González Sánchez, Mónica ; Fuente del Rey, Mónica de la | Elsevier | 2017The age-related changes in the immune functions (immunosenescence) may be mediated by an increase of oxidative stress and damage affecting leukocytes. Although the “oxidation-inflammation” theory of aging proposes that phagocytes are the main im[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, Noemí ; Corpas, Isabel ; Tresguerres, Jesús A. ; Fuente del Rey, Mónica de la | Springer | 2019-02Aging is associated with a chronic oxidative stress (increase of oxidants and decrease of antioxidants), which contributes to immunosenescence and therefore shorter longevity. Nevertheless, a positive social network has been related to the adequ[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, Noemí ; Díaz del Cerro, E. ; Félix, J. ; Fuente del Rey, Mónica de la | Elsevier | 2020-04-10Adult prematurely aging mice (PAM) show behavioral deterioration, premature immunosenescence and increased oxidative stress, impairments that are associated with their shorter lifespan, compared to the corresponding exceptional non-prematurely a[...]
