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Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Cadena Santoyo, Manuel ; Elvira Hurtado, Lorena ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2020-09-25Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes degeneration of the lower and upper motor neurons and is the most prevalent motor neuron disease. This disease is characterized by muscle weakness, stiffness, and hyp[...]texto impreso
García Martín, Elena Salobrar ; Hoyas, Irene ; Leal, Mercedes ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publising Corp. | 2015-06-08Decreased thickness of the retinal nerve fiber layer (RNFL) may reflect retinal neuronal-ganglion cell death. A decrease in the RNFL has been demonstrated in Alzheimer’s disease (AD) in addition to aging by optical coherence tomography (OCT). Tw[...]texto impreso
Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa, de ; García Martín, Elena Salobrar ; Rojas, Pilar ; Fernández Arrabal, José A. ; López Cuenca, Inés ; Rojas López, Blanca ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | IntechOpen | 2018-11The optic nerve (ON) is constituted by the axons of the retinal ganglion cells (RGCs). These axons are distributed in an organized pattern from the soma of the RGC to the lateral geniculated nucleus (where most of the neurons synapse). The key p[...]texto impreso
Gracia Pacheco, Pablo de ; Gallego Collado, Beatriz Isabel ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library of Science | 2015-11-18Proliferation of microglial cells has been considered a sign of glial activation and a hallmark of ongoing neurodegenerative diseases. Microglia activation is analyzed in animal models of different eye diseases. Numerous retinal samples are requ[...]texto impreso
Fernández Albarral, José Antonio ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | Medknow Publications | 2020-01-28Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressa[...]texto impreso
Rojas Lozano, Pilar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Ferreras, Antonio ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI AG | 2019-12Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disabi[...]texto impreso
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Sanz González, Silvia María ; García Medina, José Javier ; Zanón Moreno, Vicente ; López Gálvez, María Isabel ; Galarreta Mira, David ; Duarte, Lilianne ; Valero Velló, Mar ; Ramírez Sebastián, Ana Isabel ; Arévalo, J. Fernando ; Pinazo Durán, Mª Dolores | MDPI | 2020-11-09Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty [...]texto impreso
Bonet Fernández, Juan Manuel ; Aroca Aguilar, José Daniel ; Corton Pérez, Marta ; Ramírez Sebastián, Ana Isabel ; Alexandre Moreno, Susana ; García Antón, María Teresa ; Salazar Corral, Juan José ; Ferre Fernández, Jesús José ; Atienzar Aroca, Raquel ; Villaverde Montero, Cristina ; Iancu, Ionut ; Tamayo Durán, Alejandra ; Méndez Hernández, Carmen D. ; Morales Fernández, Laura ; Rojas López, Blanca ; Ayuso García, Carmen ; Coca Prados, Miguel ; Martínez de la Casa, Jose Maria ; García Feijoo, Julián ; Escribano, Julio | Springer-Verlag | 2020-04-09Abnormal development of the ocular anterior segment may lead to a spectrum of clinical phenotypes ranging from primary congenital glaucoma (PCG) to variable anterior segment dysgenesis (ASD). The main objective of this study was to identify the [...]texto impreso
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Pinazo Durán, Mª Dolores ; Raga Cervera, Jorge ; Sanz González, Silvia María ; Salgado Borges, José ; Benítez del Castillo, José Manuel ; Ramírez Sebastián, Ana Isabel ; Zanón Moreno, Vicente | Spanish General Council of Optometrists | 2020-04-19Purpose: To evaluate skin biocompatibility of a nighttime hydrating eyelid gel and possible ocular surface effects in contact lens users (CLU) and non-contact lens users (NCLU). The formulation is registered as a medical device as Tridocosahexae[...]texto impreso
Se ha estudiado la morfología y distribución de los astrocitos retinianos humanos mediante la inmunodeteccion de la proteína gfa en montajes planos de retina y en secciones, así como mediante m.e. se han encontrado dos tipos de astrocitos: alarg[...]texto impreso
García Antón, María Teresa ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Triviño Casado, Alberto ; Aroca Aguilar, José Daniel ; García Feijoo, Julián ; Escribano, Julio ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2017-04-27Mutations in the CYP1B1 gene are currently the main known genetic cause of primary congenital glaucoma (PCG), a leading cause of blindness in children. Here, we analyze for the first time the CYP1B1 genotype activity and the microscopic and clin[...]texto impreso
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Gallego Collado, Beatriz Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salinas Navarro, Manuel Ángel ; Ortín Martínez, Arturo ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Biomed Central Ltd | 2012-05-12Background Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons. Macroglial and microglial cells appear to play an important role in the [...]
