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Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Cadena Santoyo, Manuel ; Elvira Hurtado, Lorena ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2020-09-25Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes degeneration of the lower and upper motor neurons and is the most prevalent motor neuron disease. This disease is characterized by muscle weakness, stiffness, and hyp[...]texto impreso
Rojas Lozano, Pilar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Ferreras, Antonio ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI AG | 2019-12Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disabi[...]texto impreso
López Cuenca, Inés ; Hoz Montañana, Rosa de ; García Martín, Elena Salobrar ; Elvira Hurtado, Lorena ; Rojas Lozano, Pilar ; Fernández Albarral, José Antonio ; Barabash, Ana ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-06-03In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 y[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; Hoz Montañana, Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Rojas Lozano, Pilar ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Elsevier | 2020Glaucoma is an age-related neurodegenerative disease that begins at the onset of aging. In this disease, there is an involvement of the immune system and therefore of the microglia. The purpose of this study is to evaluate the microglial activat[...]texto impreso
García Martín, Elena Salobrar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Rojas Lozano, Pilar ; López Cuenca, Inés ; Fernández Albarral, José Antonio ; Ramirez Sebastian, Jose Manuel | Codon Publications | 2019-12-20The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Cadena Santoyo, Manuel ; Ferreras Amez, Antonio ; Monsalve Córdova, Blanca ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-01-29Background: This study compared functional and structural visual changes in Friedreich ataxia (FRDA) patients with healthy controls (HC) and correlated these changes with neurological disability. Methods: Eight FRDA Spanish patients and eight HC[...]texto impreso
García Martín, Elena Salobrar ; Méndez Hernández, Carmen D. ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; Fernández Arrabal, José A. ; Rojas Lozano, Pilar ; Wang, Surina ; García Feijoo, Julián ; Gil, Pedro ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (A?) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are r[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Cadena Santoyo, Manuel ; Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Santos García, Irene ; Lago Femia, Eva de ; Urcelay Segura, José Luis ; Ramirez Sebastian, Jose Manuel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José | MDPI | 2021-02-07The neurodegenerative disease amyotrophic lateral sclerosis (ALS) affects the spinal cord, brain stem, and cerebral cortex. In this pathology, both neurons and glial cells are affected. However, few studies have analyzed retinal microglia in ALS[...]
