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García Martín, Elena Salobrar ; Hoyas, Irene ; Leal, Mercedes ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publising Corp. | 2015-06-08Decreased thickness of the retinal nerve fiber layer (RNFL) may reflect retinal neuronal-ganglion cell death. A decrease in the RNFL has been demonstrated in Alzheimer’s disease (AD) in addition to aging by optical coherence tomography (OCT). Tw[...]texto impreso
Gracia Pacheco, Pablo de ; Gallego Collado, Beatriz Isabel ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library of Science | 2015-11-18Proliferation of microglial cells has been considered a sign of glial activation and a hallmark of ongoing neurodegenerative diseases. Microglia activation is analyzed in animal models of different eye diseases. Numerous retinal samples are requ[...]texto impreso
Fernández Albarral, José Antonio ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | Medknow Publications | 2020-01-28Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressa[...]texto impreso
Rojas Lozano, Pilar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Ferreras, Antonio ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI AG | 2019-12Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disabi[...]texto impreso
Ramos Cordero, Primitivo ; Serrano Garijo, Pilar ; Tena-Dávila Mata, Mª Cruz ; Nieto López-Guerrero, Jerónimo ; Romero Chaparro, Rosario ; García Carpio, María del Sol ; Rojos Mateo, Begoña ; Ramirez Sebastian, Jose Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, Blanca ; García Merino, José Ignacio ; Jover Ibarra, José ; Aguirre Martín-Gil, Ramón ; Pinto Fontanillo, José Antonio | Consejería de Sanidad - D. G. de Salud Pública | 2007Este documento, que constituye el nº 8 de la colección Promoción de la salud en las personas mayores, pretende abordar buena parte de los problemas de salud de este colectivo aportando criterios y metodología para la intervención a sus cuidadore[...]texto impreso
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Gallego Collado, Beatriz Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salinas Navarro, Manuel Ángel ; Ortín Martínez, Arturo ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Biomed Central Ltd | 2012-05-12Background Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons. Macroglial and microglial cells appear to play an important role in the [...]texto impreso
Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; García Martín, Elena Salobrar ; Valiente Soriano, Francisco Javier ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Elsevier | 2015Most studies employing experimental models of unilateral glaucoma have used the normotensive contralateral eye as the normal control. However, some studies have recently reported the activation of the retinal macroglia and microglia in the uninj[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ruiz, Emilio ; Tejerina Sánchez, Teresa ; Ramirez Sebastian, Jose Manuel ; Triviño Casado, Alberto | Elsevier | 2006-09-26This study evaluates hypercholesterolemic rabbits, examining the retinal changes in Müller cells and astrocytes as well as their variations after a period of normal blood-cholesterol values induced by a standard diet. New Zealand rabbits were di[...]texto impreso
Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto | BioMed Central Ltd. | 2014-07-26Background: Glaucomatous optic neuropathy, a leading cause of blindness, can progress despite control of intraocular pressure - currently the main risk factor and target for treatment. Glaucoma progression shares mechanisms with neurodegenerativ[...]texto impreso
Fernández Navarro, Judith ; Aldea Mansilla, Pilar ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Rojas López, Blanca ; Gallego Collado, Beatriz Isabel ; Triviño Casado, Alberto ; Tejerina Sánchez, Teresa ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2016-05-04To evaluate the pleiotropic effects to statins, we analyze the qualitative and quantitative retinal changes in hypercholesterolemic rabbits after a low-dosage statin treatment. For this purpose, New Zealand rabbits were split into three groups: [...]texto impreso
García Martín, Elena Salobrar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Rojas Lozano, Pilar ; López Cuenca, Inés ; Fernández Albarral, José Antonio ; Ramirez Sebastian, Jose Manuel | Codon Publications | 2019-12-20The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Cadena Santoyo, Manuel ; Ferreras Amez, Antonio ; Monsalve Córdova, Blanca ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-01-29Background: This study compared functional and structural visual changes in Friedreich ataxia (FRDA) patients with healthy controls (HC) and correlated these changes with neurological disability. Methods: Eight FRDA Spanish patients and eight HC[...]texto impreso
García Martín, Elena Salobrar ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil Gregorio, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publishing Corporation | 2015-05-20Purpose. To analyze in mild Alzheimer's disease (MAD) patients, GDS-4 (Reisberg Scale), whether or not some psychophysical tests (PTs) support OCT macular findings in the same group of MAD patients reported previously. Methods. Twenty-three MAD [...]texto impreso
Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; Martínez Páramo, Rebeca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | Elsevier | 2018-10-28Alzheimer's disease (AD) is a neurodegenerative dementia characterized by the deposition of extracellular ?-amyloid (A?) plaques and the presence of neurofibrillary tangles. Until now, the techniques used to analyze these deposits have been diff[...]
