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Sacristán Reviriego, Almudena ; Madrid, Marisa ; Cansado, José ; Martín, Humberto ; Molina, María | Public Library of Science | 2014-01-22Dual-specificity MAPK phosphatases (MKPs) are essential for the negative regulation of MAPK pathways. Similar to other MAPK-interacting proteins, most MKPs bind MAPKs through specific docking domains known as D-motifs. However, we found that the[...]texto impreso
Martín, Humberto ; Shales, Michael ; Fernández-Piñar, Pablo ; Wei, Ping ; Molina, María ; Fiedler, Dorothea ; Shokat, Kevan M. ; Beltrao, Pedro ; Lim, Wendell ; Krogan, Nevan J. | EMBO Press | 2015-04-17Genetic interaction screens have been applied with great success in several organisms to study gene function and the genetic architecture of the cell. However, most studies have been performed under optimal growth conditions even though many fun[...]texto impreso
The lack of signaling through MAPK pathways leads to a defective cellular response to the corresponding stimulus, but an improper hyperactivation of these routes results in deleterious effects as well. Protein phosphorylation is an activating mo[...]texto impreso
González Rubio, Gema ; Fernández Acero, Teresa ; Martín, Humberto ; Molina Martín, María | MDPI | 2019-04-05Mitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. Since the precise regulation of MAPKs is fundamental for cell physiology, fungi [...]texto impreso
Mascaraque, Victoria ; Hernaez, Maria Luisa ; Jiménez-Sánchez, María ; Hansen, Rasmus ; Gil, Concha ; Martín, Humberto ; Cid, Víctor J. ; Molina, María | 2013-03The cell wall integrity (CWI) pathway of the model organism Saccharomyces cerevisiae has been thoroughly studied as a paradigm of the mitogen-activated protein kinase (MAPK) pathway. It consists of a classic MAPK module comprising the Bck1 MAPK [...]texto impreso
Fernández-Piñar, Pablo ; Alemán, Ainel ; Sondek, John ; Dohlman, Henrik G. ; Molina, María ; Martín, Humberto | 2012-09-26Intracellular survival of Salmonella relies on the activity of proteins translocated into the host cell by type III secretion systems (T3SS). The protein kinase activity of the T3SS effector SteC is required for F-actin remodeling in host cells,[...]
