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Yang, Hailin ; Kim, Sung-Kwon ; Kim, Mikyung ; Reche, Pedro A ; Morehead, Tiara J ; Damon, Inger K ; Welsh, Raymond M ; Reinherz, Ellis L | American Society for Clinical Investigation | 2005The EGF-like domain of smallpox growth factor (SPGF) targets human ErbB-1, inducing tyrosine phosphorylation of certain host cellular substrates via activation of the receptor's kinase domain and thereby facilitating viral replication. Given the[...]texto impreso
Kim, Mikyung ; Yang, Hailin ; Kim, Sung-Kwon ; Reche, Pedro A ; Tirabassi, Rebecca S ; Hussey, Rebecca E ; Chishti, Yasmin ; Rheinwald, James G ; Morehead, Tiara J ; Zech, Tobias ; Damon, Inger K ; Welsh, Raymond M ; Reinherz, Ellis L | American Society for Biochemistry and Molecular Biology | 2004Variola, the causative agent of smallpox, is a highly infectious double-stranded DNA virus of the orthopox genus that replicates within the cytoplasm of infected cells. For unknown reasons prominent skin manifestations, including "pox," mark the[...]texto impreso
Identification of peptides that can bind to major histocompatibility complex (MHC) molecules is important for anticipation of T-cell epitopes and for the design of epitope-based vaccines. Population coverage of epitope vaccines is, however, comp[...]texto impreso
Moody, A M ; Chui, D ; Reche, Pedro A ; Priatel, J J ; Marth, J D ; Reinherz, Ellis L | 2001The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to[...]texto impreso
Reche, Pedro A ; Keskin, Derin B ; Hussey, Rebecca E ; Ancuta, Petronela ; Gabuzda, Dana ; Reinherz, Ellis L | BioMed Central | 2006Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that ma[...]texto impreso
We introduced previously an on-line resource, RANKPEP that uses position specific scoring matrices (PSSMs) or profiles for the prediction of peptide-MHC class I (MHCI) binding as a basis for CD8 T-cell epitope identification. Here, using PSSMs t[...]texto impreso
Reche, Pedro A ; Zhang, Hong ; Glutting, John-Paul ; Reinherz, Ellis L | Oxford University Press | 2005EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently, the database contains 4867 distinct peptide sequences from various sources, including 84 tumor-associated antigens. The EP[...]texto impreso
Zhong, Weimin ; Reche, Pedro A ; Lai, Char-Chang ; Reinhold, Bruce ; Reinherz, Ellis L | American Society for Biochemistry and Molecular Biology | 2003A genome-wide search using major histocompatibility complex (MHC) class I binding and proteosome cleavage site algorithms identified 101 influenza A PR8 virus-derived peptides as potential epitopes for CD8+ T cell recognition in the H-2b mouse. [...]texto impreso
Fridkis-Hareli, Masha ; Reche, Pedro A ; Reinherz, Ellis L | 2004During development, thymocytes carrying TCRs mediating low-affinity interactions with MHC-bound self-peptides are positively selected for export into the mature peripheral T lymphocyte pool. Thus, exogenous administration of certain altered pept[...]texto impreso
Reche, Pedro A ; Reinherz, Ellis L | 2005Prediction of peptide binding to major histocompatibility complex (MHC) molecules is a basis for anticipating T-cell epitopes, as well as epitope discovery-driven vaccine development. In the human, MHC molecules are known as human leukocyte anti[...]texto impreso
DNA methylation plays a key role in the regulation of gene expression. The most common type of DNA modification consists of the methylation of cytosine in the CpG dinucleotide. At the present time, there is no method available for the prediction[...]texto impreso
Peptides that bind to a given major histocompatibility complex (MHC) molecule share sequence similarity. Therefore, a position specific scoring matrix (PSSM) or profile derived from a set of peptides known to bind to a specific MHC molecule woul[...]texto impreso
Reche, Pedro A ; Reinherz, Ellis L | 2007Prediction of peptide binding to major histocompatibility complex (MHC) molecules is a basis for anticipating T-cell epitopes. Peptides that bind to a given MHC molecule are related by sequence similarity. Therefore, a position-specific scoring [...]texto impreso
García Boronat, María ; Díez Rivero, Carmen M. ; Reinherz, Ellis L ; Reche, Pedro A | Oxford University Press | 2008We have developed PVS (Protein Variability Server), a web-based tool that uses several variability metrics to compute the absolute site variability in multiple protein-sequence alignments (MSAs). The variability is then assigned to a user-select[...]texto impreso
Bhasin, Manoj ; Reinherz, Ellis L ; Reche, Pedro A | 2006Histones are DNA-binding proteins found in the chromatin of all eukaryotic cells. They are highly conserved and can be grouped into five major classes: H1/H5, H2A, H2B, H3, and H4. Two copies of H2A, H2B, H3, and H4 bind to about 160 base pairs [...]
