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Debido a su similitud estructural con el glutamato, el ?-N-metilamino-L-alanina (L-BMAA) va a tener una acción excitotóxica causando alteraciones en el interior de las células, como son un incremento del estrés oxidativo, una disfunción mitocond[...]texto impreso
Muñoz Sáez, Emma ; Munck García, Estefanía de ; Arahuetes Portero, Rosa Mª ; Martínez, Ana ; Solas Alado, Mª Teresa ; Gómez Miguel, Begoña | Elsevier | 2015-05Due to its structural similarity to glutamate, L-BMAA could be a trigger for neurodegenerative disorders caused by changes in the intracellular medium, such as increased oxidative stress, mitochondrial dysfunction, impaired synthesis and protein[...]texto impreso
Munck García, Estefanía de ; Muñoz Sáez, Emma ; Gómez Miguel, Begoña ; Solas Alados, Mª Teresa ; Martínez, Ana ; Arahuetes, Rosa María | Elsevier | 2015-05Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle paralysis that reflects the motoneurons’ degeneration. Several studies support the relationship between ?-N-methylamino-L-alanine (L-BMAA), a [...]texto impreso
Muñoz Sáez, Emma ; Munck García, Estefanía de ; Arahuetes Portero, Rosa María ; Vicente, Francisca ; Ortiz López, Francisco Javier ; Cantizani, Juan ; Gómez Miguel, Begoña | Elsevier | 2015-04-23Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino aci[...]texto impreso
Munk, Estefanía de ; Palomo, Valle ; Muñoz Sáez, Emma ; Pérez, Daniel I. ; Gómez Miguel, Begoña ; Solas Alados, Mª Teresa ; Gil, Carmen ; Martínez, Ana ; Arahuetes Portero, Rosa María | Public Library of Sciences (PLOS) | 2016-09-15Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the l[...]
