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Ruwisch, Jannik ; Sehlmeyer, Kirsten ; Roldán López, Nuria ; García Álvarez, Begoña ; Pérez-Gil, Jesús ; Weaver, Timothy E. ; Ochs, Matthias ; Knudsen, Lars ; López-Rodríguez, Elena | American Thoracic Society | 2020-01-10Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling in aging mice and alveolar l[...]texto impreso
Mato, Aranzazu ; Blanco, Francisco G. ; Maestro, Beatriz ; Sanz, Jesús M. ; Pérez-Gil, Jesús ; Prieto, M. Auxiliadora | American Society for Microbiology | 2020-06-02Phasin PhaF from Pseudomonas putida consists of a modular protein whose N-terminal domain (BioF) has been demonstrated to be responsible for binding to the polyhydroxyalkanoate (PHA) granule. BioF has been exploited for biotechnological purposes[...]texto impreso
Mato, Aranzazu ; Tarazona Lizcano, Natalia Andrea ; Hidalgo Román, Alberto ; Cruz Rodríguez, Antonio ; Jiménez, Mercedes ; Pérez-Gil, Jesús ; Prieto Jiménez, María Auxiliadora | American Chemical Society | 2019-01Phasins, the major proteins coating polyhydroxyalkanoate (PHA) granules, have been proposed as suitable biosurfactants for multiple applications because of their amphiphilic nature. In this work, we analyzed the interfacial activity of the amphi[...]texto impreso
Cañadas Benito, Olga ; Olmeda Lozano, Bárbara ; Alonso Eugenio, Alejandro ; Pérez-Gil, Jesús | MDPI | 2020-05-25Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air–liquid interface. Surfactant, assembled as a complex network of membran[...]texto impreso
Martínez Calle, Marta ; Alonso Eugenio, Alejandro ; Pérez-Gil, Jesús ; Olmeda Lozano, Bárbara | Elsevier | 2019-09Pulmonary surfactant is a lipid-protein complex which coats lung alveoli. It displays the essential function of reducing surface tension at the air-liquid interface, avoiding alveolar collapse during expiration. The optimized biophysical propert[...]texto impreso
Autilio, Chiara ; Echaide Torreguitar, Mercedes ; Benachi, Alexandra ; Marfaing-Koka, Anne ; Capoluongo, Ettore D. ; Pérez-Gil, Jesús ; De Lucca, Daniele | Elsevier | 2017-03Objective: To determine the diagnostic accuracy of the surfactant adsorption test (SAT) as a predictor for the need for surfactant replacement therapy in neonates with respiratory distress syndrome (RDS). Study design Amniotic fluid samples were[...]texto impreso
Sørli, Jorid B. ; Låg, Marit ; Ekerenb, Leni ; Pérez-Gil, Jesús ; Haug, Line S. H ; Da Silva, Emilie ; Matrod, Muhammad N. ; Gützkow, Kristine B. ; Lindeman, Birgitte | Elsevier | 2020-02The toxicity of some per- and polyfluoroalkyl substances (PFASs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been studied thoroughly, showing that systemic PFASs targets the lungs. However, regulators lack dat[...]texto impreso
López-Rodríguez, Elena ; Roldán López, Nuria ; García-Álvarez, Begoña ; Pérez-Gil, Jesús | American Society for Biochemistry and Molecular Biology | 2019-02Traditionally, thin layer chromatography (TLC) has been used for the analysis of lipids isolated from membrane complexes. Here, we describe a method based on the combination of TLC and SDS-polyacrylamide gel electrophoresis (SDS-PAGE) for the qu[...]texto impreso
Liekkinen, Juho ; Enkavi, Giray ; Javanainen, Matti ; Olmeda Lozano, Bárbara ; Pérez-Gil, Jesús ; Vattulainen, Ilpo | Elsevier | 2020-05-02Surfactant protein B (SP-B) is essential in transferring surface-active phospholipids from membrane-based surfactant complexes into the alveolar air–liquid interface. This allows maintaining the mechanical stability of the surfactant film under [...]texto impreso
Arroyo, Raquel ; Khan, MerajAlam ; Echaide Torreguitar, Mercedes ; Pérez-Gil, Jesús ; Palaniyar, Nades | Nature Research | 2019-12-16An exacerbated amount of neutrophil extracellular traps (NETs) can cause dysfunction of systems during inflammation. However, host proteins and factors that suppress NET formation (NETosis) are not clearly identified. Here we show that an innate[...]texto impreso
Autilio, Chiara ; Echaide Torreguitar, Mercedes ; Shankar-Aguilera, Shivani ; Bragado Herrero, Rafael ; Amidani, Davide ; Salomone, Fabrizio ; Pérez-Gil, Jesús ; De Luca, Daniele | American Thoracic Society | 2020-04-20Rationale. No in vivo data are available about the effect of meconium on human surfactant in the early stages of severe meconium aspiration syndrome (MAS). Objectives. To characterize the changes in surfactant composition, function and structure[...]
