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Jiménez Álvarez, Sara ; López Redondo, Jesús María ; Lozano, Daniel ; Morona Arribas, Ruth ; Zapata González, Agustín ; Moreno García, Nerea | Springer | 2020-08-02The organization of the pallial derivatives across vertebrates follows a comparable elementary arrangement, although not all of them possess a layered cortical structure as sophisticated as the cerebral cortex of mammals. However, its expansion [...]texto impreso
Muñoz, Juan José ; García Ceca Hernández, Javier ; Montero Herradón, Sara ; Sánchez del Collado, Beatriz ; Alfaro Sánchez, David ; Zapata González, Agustín | Frontiers Media | 2018-04-03For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), hav[...]texto impreso
Cejalvo, Teresa ; Muñoz, Juan J. ; Tobajas, Esther ; Alfaro Sánchez, David ; García Ceca Hernández, Javier ; Zapata González, Agustín | Springer Link | 2015-05Our understanding about medullary compartment, its niches composition and formation is still limited. Previous studies using EphB2 and/or EphB3 knockout mice showed an abnormal thymic development that affects mainly to the epithelial component, [...]texto impreso
Montero Herradón, Sara ; Garcia-Ceca Hernández, Javier ; Sánchez del Collado, Beatriz ; Zapata González, Agustín | 2016-08Thymus development is a complex process in which cell-to-cell interactions between thymocytes and thymic epithelial cells (TECs) are essential to allow a proper maturation of both thymic cell components. Although signals that control thymocyte d[...]texto impreso
García Ceca Hernández, Javier ; Alfaro Sánchez, David ; Montero Herradón, Sara ; Tobajas, Esther ; Muñoz, Juan José ; Zapata González, Agustín | Frontiers Media | 2015-06-26Numerous studies emphasize the relevance of thymocyte–thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and th[...]texto impreso
Alfaro Sánchez, David ; Garcia Ceca Hernández, José Javier ; Farias de Oliveira, Desio A. ; Terra Granado, Eugenia ; Montero Herradón, Sara ; Cotta de Almeida, Vinicius ; Savino, Wilson ; Zapata González, Agustín | 2015-02Adult thymuses lacking either ephrin type B receptor 2 (EphB2) or EphB3, or expressing a truncated form of EphB2, the forward signal-deficient EphB2LacZ, have low numbers of early thymic progenitors (ETPs) and are colonized in vivo by reduced nu[...]texto impreso
EphrinA4 plays a critical role in ?4 and ?L mediated survival ofhuman CLL cells during extravasation
Flores, Miguel A. ; Fortea Gordo, Paula ; Trinidad, Eva M. ; García, Dolores ; Soler, Gloria ; Ortuño, Francisco J. ; Zapata González, Agustín ; Alonso Colmenar, Luis Miguel | Impact journals | 2016-06A role of endothelial cells in the survival of CLL cells during extravasation is presently unknown. Herein we show that CLL cells but not normal B cells can receive apoptotic signals through physical contact with TNF-? activated endothelium impa[...]texto impreso
Garcia-Ceca Hernández, Javier ; Montero Herradón, Sara ; Alfaro Sánchez, David ; Zapata González, Agustín | Springer Link | 2017-05-24Epithelial-free areas, present in both thymic cortex and medulla, have been studied in WT and EphB-deficient mice that have important alterations in the development of thymic epithelium due to the lack of proper thymocyte–thymic epithelial cell [...]texto impreso
Garcia-Ceca Hernández, Javier ; Montero Herradón, Sara ; Zapata González, Agustín | MDPI | 2020-10-02Intimate interactions between thymic epithelial cells (TECs) and thymocytes (T) have been repeatedly reported as essential for performing intrathymic T-cell education. Nevertheless, it has been described that animals exhibiting defects in these [...]texto impreso
Fañanas-Baquero, Sara ; Orman, Israel ; Becerra Aparicio, Federico ; Bermudez de Miguel, Silvia ; Garcia Merino, Jordi ; Yañez, Rosa ; Fernández Sainz, Yolanda ; Sánchez, Rebeca ; Dessy-Rodríguez, Mercedes ; Alberquilla, Omaira ; Alfaro Sánchez, David ; Zapata González, Agustín ; Bueren, Juan A. ; Segovia, Jose Carlos ; Quintana-Bustamante, Oscar | Ferrata Storti Foundation | 2020-04Hematopoietic Stem and Progenitor Cells are crucial in the maintenance of lifelong production of all blood cells. These Stem Cells are highly regulated to maintain homeostasis through a delicate balance between quiescence, self-renewal and diffe[...]texto impreso
Ontoria Oviedo, Imelda ; Martínez, Víctor G. ; Ricardo, Carolina P. ; Harding, Sian E. ; Sacedón, Rosa ; Varas, Alberto ; Zapata González, Agustín ; Sepulveda, Pilar ; Vicente, Ángeles | Cross Mark | 2017Background: Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs. Hypoxia-preconditioning and [...]texto impreso
Sánchez Guijo, Fermín ; García Olmo, Damián ; Prósper, Felipe ; Martínez, Salvador ; Zapata González, Agustín ; Fernández Avilés, Francisco ; Toledo Aral, Juan José ; Torres, Miguel ; Fariñas, Isabel ; Badimón, Lina ; Labandeira García, José Luis ; García Sancho, Javier ; Moraleda, Jose María | Elsevier | 2019-12-19In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful collaborative public initiative funded by the Spanish government for the support of nationwide translational research in this i[...]texto impreso
Bednarek, Dorota ; González Rosa, Juan Manuel ; Guzmán Martínez, Gabriela ; Gutiérrez Gutiérrez, Óscar ; Aguado, Tania ; Sánchez Ferrer, Carlota ; Joao Marques, Ines ; Galardi Castilla, María ; Diego, Irene de ; Gómez, Manuel José ; Cortés, Alfonso ; Zapata González, Agustín ; Jiménez Borreguero, Luis Jesús ; Mercader, Nadia ; Flores, Ignacio | Cross Mark | 2015After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast, zebrafish hearts efficiently regenerate after injury. Complete regeneration of the zebrafish heart is driven by the strong pro[...]texto impreso
Garcia-Ceca Hernández, Javier ; Montero-Herradón, Sara ; Zapata González, Agustín | Wiley | 2020-10-20Background: The epithelial microenvironment is involved in thymus aging, but the possible role of EphB receptors that govern the thymic epithelium development has not been investigated. Herein, we study the changes undergone by the thymus of Eph[...]
