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Granier, Sophie A ; Hidalgo, Laura ; San Millán, Álvaro ; Escudero, José Antonio ; Gutiérrez, Belén ; Brisabois, Anne ; González Zorn, Bruno | American Society for Microbiology | 2011-11The 16S rRNA methyltransferase ArmA is a worldwide emerging determinant that confers high-level resistance to most clinically relevant aminoglycosides. We report here the identification and characterization of a multidrug-resistant Salmonella en[...]texto impreso
Hidalgo, Laura ; Hopkins, Katie L ; Wareham, David W ; Gutiérrez, Belén ; González Zorn, Bruno | American Society for Microbiology | 2012-09Aminoglycosides and beta-lactams are used for the treatment of a wide range of infections due to both Gram-negative and Gram-positive. An emerging aminoglycoside resistance mechanism, methylation of the aminoacyl site of the 16S rRNA, confers [...]texto impreso
Valencia Mahón, Jaris ; Jiménez, Eva ; Martínez, Víctor G. ; Amo, Beatriz G. del ; Hidalgo, Laura ; Entrena Martínez, Ana ; Fernández Sevilla, Lidia M. ; Río, Francisco del ; Varas, Alberto ; Vicente, Ángeles ; Sacedón, Rosa | Cross Mark | 2017Fibroblastic reticular cells (FRCs) are essential players during adaptive immune responses not only as a structural support for the encounter of antigen-presenting cells and naive T lymphocytes but also as a source of modulatory signals. However[...]texto impreso
Gutiérrez, Belén ; Escudero, José Antonio ; San Millán, Álvaro ; Hidalgo, Laura ; Carrilero Aguado, Laura ; Martínez Ovejero, Cristina ; Santos López, Alfonso ; Thomas López, Daniel ; González Zorn, Bruno | American Society for Microbiology | 2012-05Arm/Rmt methyltransferases have emerged recently in pathogenic bacteria as enzymes that confer high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA (like ArmA and RmtA to -E). In pro[...]texto impreso
Escudero, José Antonio ; San Millán, Álvaro ; Gutiérrez, Belén ; Hidalgo, Laura ; La Ragione, Roberto M ; AbuOun, Manal ; Galimand, Marc ; Ferrándiz, María José ; Domínguez Rodríguez, Lucas ; de la Campa, Adela G ; González Zorn, Bruno | American Society for Microbiology | 2011-12Streptococcus suis is an emerging zoonotic pathogen. With the lack of an effective vaccine, antibiotics remain the main tool to fight infections caused by this pathogen. We have previously observed a reserpine-sensitive fluoroquinolone (FQ) effl[...]texto impreso
San Millán, Álvaro ; Garcia Cobos, Silvia ; Escudero, José Antonio ; Hidalgo, Laura ; Gutiérrez, Belén ; Carrilero Aguado, Laura ; Campos, José ; González Zorn, Bruno | American Society for Microbiology | 2010-04Plasmid pB1000 is a mobilizable replicon bearing the bla(ROB-1) beta-lactamase gene that we have recently described in Haemophilus parasuis and Pasteurella multocida animal isolates. Here we report the presence of pB1000 and a derivative plasmid[...]texto impreso
Hidalgo, Laura ; Gutiérrez, Belén ; Martínez Ovejero, Cristina ; Carrilero Aguado, Laura ; Matrat, Stephanie ; Saba, Courage K S ; Santos López, Alfonso ; Thomas López, Daniel ; Hoefer, Andreas ; Suárez Rodríguez, Mónica ; Santurde Sánchez, Gloria ; Martín Espada, Carmen ; González Zorn, Bruno | American Society for Microbiology | 2013-09Seven Klebsiella pneumoniae isolates from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by multilocus sequence typing (MLST) as[...]texto impreso
San Millán, Álvaro ; Escudero, José Antonio ; Gutiérrez, Belén ; Hidalgo, Laura ; Garcia, Nerea ; Llagostera, Montserrat ; Domínguez Rodríguez, Lucas ; González Zorn, Bruno | American Society for Microbiology | 2009-08In most gram-negative bacteria, acquired multiresistance is conferred by large plasmids compiling numerous antimicrobial resistance genes. Here, we show an evolutionary alternative strategy used by Pasteurella multocida to become resistant to mu[...]texto impreso
Robson, Neil C. ; Hidalgo, Laura ; McAlpine, Tristan ; Wei, Heng ; Martínez, Víctor G. ; Entrena Martínez, Ana ; Melen, Gustavo J. ; MacDonald, Andrew S. ; Phythian-Adams, Alexander ; Sacedón, Rosa ; Maraskovsky, Eugene ; Cebon, Jonathan ; Ramírez, Manuel ; Vicente, Ángeles ; Varas, Alberto | American Association for Cancer Research | 2018-09Natural killer (NK) cells are critical for innate tumor immunity due to their specialized ability to recognize and kill neoplastically transformed cells. However, NK cells require a specific set of cytokine-mediated signals to achieve optimal ef[...]
