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Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; González Álvaro, Isidoro ; Rodríguez Frade, José Miguel ; Mellado, Mario ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Nature Research | 2019-05-14Vasoactive Intestinal Peptide (VIP) is an important immunomodulator of CD4+ cells in normal and pathological conditions, which exerts its anti-infammatory and immunomodulatory actions through VPAC receptors, VPAC1 and VPAC2. Only a decrease in t[...]texto impreso
Rodríguez Frade, José Miguel ; Martínez Muñoz, Laura ; Villares, Ricardo ; Cascio, Graciela ; Lucas, Pilar ; Pérez Gomáriz, Rosa María ; Mellado, Mario | Elsevier | 2016Chemokines and their receptors take part in many physiological and pathological processes, and their dysregulated expression is linked to chronic inflammatory and autoimmune diseases, immunodeficiencies, and cancer. The chemokine receptors, memb[...]texto impreso
Martínez, Carmen ; Juarranz Moratilla, Yasmina ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; Castro Moreno, David ; Lamana, Amalia ; Mellado, Mario ; González Álvaro, Isidoro ; Gomáriz, Rosa P. | MDPI | 2019-12-20The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through shared mediators and receptors. Vasoactive intestinal peptide (VIP) is the paradigm of an endogenou[...]texto impreso
Pérez García, Selene ; Gutiérrez Cañas, Irene ; Seoane Valiño, Iria V. ; Fernández, Julián ; Mellado, Mario ; Leceta Martínez, Javier ; Tío, Laura ; Villanueva Romero, Raúl ; Juarranz Moratilla, Yasmina ; Pérez Gomáriz, Rosa María | 2016-09Current description of osteoarthritis includes the involvement of synovial inflammation. Studies contributing to understanding the mechanisms of cross-talk and feedback among the joint tissues could be relevant to the development of therapies th[...]texto impreso
Lamana, Amalia ; Villares, Ricardo ; Seoane Valiño, Iria V. ; Andrés, Nuria ; Lucas, Pilar ; Emery, Paul ; Vital, Edward M. ; Triguero-Martínez, Ana ; Márquez, Ana ; Ortiz, Ana M. ; Maxime, Robin ; Martínez, Carmen ; Martín, Javier ; Gomáriz, Rosa P. ; Ponchel, Frederique ; González-Álvaro, Isidoro ; Mellado, Mario | Frontiers Media | 2020-06-26Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an autoimmune response in the joints and an exacerbation of cytokine responses. A minority of patients with RA experience spontaneous remission, but most will show mode[...]texto impreso
Villares, Ricardo ; Criado, Gabriel ; Juarranz Moratilla, Yasmina ; López Santalla, Mercedes ; García-Cuesta, Eva María ; Rodríguez Frade, José Miguel ; Leceta Martínez, Javier ; Lucas, Pilar ; Pablos, José L. ; Martínez-A., Carlos ; Garin, Marina I. ; Gomáriz, Rosa P. ; Mellado, Mario | Frontiers Media | 2018-05-25Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several[...]texto impreso
Jimeno, Rebeca ; Leceta Martínez, Javier ; Garín, Marina ; Ortiz, Ana M. ; Mellado, Mario ; Rodríguez Frade, José Miguel ; Martínez, Carmen ; Pérez García, Selene ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | The Society for Leukocyte Biology. | 2015-08Several studies in humans indicate the implication of Th17 cells in RA. Therapies targeting their pathogenicity, as well as their plasticity to the Th17/1 phenotype, could ameliorate the progression of the pathology. The neuroendocrine environme[...]texto impreso
D’Agostino, Gianluca ; García-Cuesta, Eva María ; Gomáriz, Rosa P. ; Rodríguez-Frade, José Miguel ; Mellado, Mario | Elsevier | 2020-03-05The chemokines receptor family are membrane-expressed class A-specific seven-transmembrane receptors linked to G proteins. Through interaction with the corresponding ligands, the chemokines, they induce a wide variety of cellular responses inclu[...]texto impreso
Jimeno Lumeras, Rebeca Gema ; Leceta Martínez, Javier ; Martínez, Carmen ; Gutiérrez-Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Garín, Marina ; Mellado, Mario ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | Springer | 2014-11The cytokine microenvironment modulates CD4 T cell differentiation causing the shift of naïve CD4 T cells into different cell subsets. This process is also regulated by modulators such as VIP, a neuropeptide with known immunomodulatory propertie[...]texto impreso
Pérez García, Selene ; Carrión Caballo, Mar ; Villanueva Romero, Raúl ; Hermida Gómez, Tamara ; Fernández Moreno, Mercedes ; Mellado, Mario ; Blanco, Francisco J. ; Juarranz Moratilla, Yasmina ; Gomáriz, Rosa P. | Wiley Open Acces | 2019Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expres? sion in homeostasis, together with their network complexity. The knowledge o[...]
