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Álvarez García, Elisa ; Batanero Cremades, Eva ; García Fernández, Rosa ; Villalba Díaz, María Teresa ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Esmon Publicidad | 2010-03?-Sarcin is a natural variant of Asp f 1 produced by the nonpathogenic fungus Aspergillus giganteus. Both proteins show a sequence identity of 87% and almost identical 3-dimensional structures. ?-Sarcin ?(7-22) is a deletion mutant that displays[...]texto impreso
Lacadena, Javier ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Herrero Galán, Elías ; Alegre Cebollada, Jorge ; García Ortega, Lucía ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007RNase T1 is the best known representative of a large family of ribonucleolytic proteins secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among them by their cytotoxic character. They exert their toxic action by[...]texto impreso
Herrero Galán, Elías ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Gavilanes, José G. | Caister Academic Press | 2009Ribotoxins are a family of fungal extracellular ribonucleases which inactivate ribosomes by specifically cleaving a single phosphodiester bond located at the universally conserved sarcin/ricin loop of the large rRNA. The subsequent inhibition of[...]texto impreso
Álvarez García, Elisa ; García Ortega, Lucía ; De los Ríos, Vivian ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2009Ribonuclease U2, secreted by the smut fungus Ustilago sphaerogena, is a cyclizing ribonuclease that displays a rather unusual specificity within the group of microbial extracellular RNases, best represented by RNase T1. Superposition of the thre[...]texto impreso
Álvarez García, Elisa ; Alegre Cebollada, Jorge ; Batanero Cremades, Eva ; Monedero, Vicente ; Pérez Martínez, Gaspar ; García Fernández, Rosa ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007-06-25Fungal ribotoxins are a family of extracellular ribonucleases which inhibit protein biosynthesis by inactivating the ribosomes. This inactivation results in the induction of cell death by apoptosis. Ribotoxins show antitumoral properties based o[...]texto impreso
La ribonucleasa T1 es la proteína más representativa y mejor conocida de toda una gran familia de ribonucleasas secretadas por hongos, principalmente por especies de los géneros "Aspergillus y Penicillium". Dentro de esta familia destacan las ri[...]texto impreso
Ribotoxins are a family of toxic extracellular fungal RNases that first enter into the cells and then exert a highly specific ribonucleolytic activity on the larger rRNA molecule, leading to protein synthesis inhibition and cell death by apoptos[...]texto impreso
Álvarez García, Elisa ; Diago Navarro, Elizabeth ; Herrero Galán, Elías ; García Ortega, Lucía ; López Villarejo, Juan ; Olmo López, Nieves ; Díaz Orejas, Ramón ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2011Fungal ribotoxins are toxic secreted ribonucleases that cleave a conserved single phosphodiester bond located at the sarcin/ricin loop of the larger rRNA. This cleavage inactivates ribosomes leading to protein biosynthesis inhibition and cell de[...]texto impreso
Carreras Sangrà, Nelson ; Álvarez García, Elisa ; Herrero Galán, Elías ; Tomé, Jaime ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Bentham Science Publishers Ltd. | 2008Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin–ricin loop. This cleavage of a single phosphodiester bond inactiv[...]
