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Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Spanish General Council of Optometrists | 2017-11Purpose/aim: Glaucoma consists of a group of progressive optic neuropathies that are characterized by degeneration of the optic nerve and irreversible visual filed loss. Elevated intraocular pressure is the only proven treatable risk factor and [...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Elsevier | 2015-05The effect of the dinucleotide P1, P4-Di (adenosine-5') tetraphosphate (Ap4A) in improving adrenergic anti-glaucomatous delivery by modifying the tight junction proteins of the corneal epithelium was evaluated. Stratified human corneal epithelia[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | The British Pharmacological Society / Wiley-Blackwell | 2015-02BACKGROUND AND PURPOSE: Here, we have studied the effects of the dinucleotide P1, P4-Di (adenosine-5?) tetraphosphate (Ap4A) on corneal barrier function conferred by the tight junction (TJ) proteins and its possible involvement in ocular drug de[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Taylor & Francis | 2016-09Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples[...]texto impreso
Pelaez, Teresa ; Mediero Muñoz, Aránzazu ; Alarma-Estrany, Pilar ; Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Crooke, Almudena ; Kolligris, Basilio ; Peral Cerdá, Assumpta ; Pintor, Jesús | Real Academia Nacional de Farmacia | 2007The research on the effect of melatonin on intraocular pressure (IOP) is reviewed from the hystorical point of view of our laboratory. The original idea of melatonin modulating intraocular pressure has been improved by using selective compounds[...]texto impreso
El Ap4A es una molécula con un amplio papel biológico en el ojo. Se ha descrito su implicación en procesos de secreción lagrimal, cicatrización epitelial, regulación de la presión intraocular, y presenta también un papel neuroprotector sobre los[...]
