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Palacios Ortega, Juan ; García Linares, Sara ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | ACS | 2017In this study, we examined the influence of bilayer thickness on the activity of the actinoporin toxins sticholysin I and II (StnI and StnII) at 25 °C. Bilayer thickness was varied using dimonounsaturated phosphatidylcholine (PC) analogues (with[...]texto impreso
Palacios Ortega, Juan ; Rivera-de-Torre, Esperanza ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | Elsevier | 2020-04-21Release of aqueous contents from model lipid vesicles has been a standard procedure to evaluate pore formation efficiency by actinoporins, such as sticholysin II (StnII), for the last few decades. However, regardless of the probe of choice, the [...]texto impreso
Palacios Ortega, Juan ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | Elsevier | 2020-09-01Release of aqueous contents from model lipid vesicles has been a standard procedure to evaluate pore formation efficiency by actinoporins, such as sticholysin II (StnII), for the last few decades. However, regardless of the probe of choice, the [...]texto impreso
Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Slotte, J. Peter ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Linares, Sara | MDPI | 2020-11Venoms constitute complex mixtures of many different molecules arising from evolution in processes driven by continuous prey–predator interactions. One of the most common compounds in these venomous cocktails are pore-forming proteins, a family [...]texto impreso
García Ortega, Lucía ; Palacios Ortega, Juan ; Martínez del Pozo, Álvaro | Wiley Online Library | 2018-02-16Fungal ribotoxins constitute a family of extracellular ribonucleases with exquisite specificity against rRNA (ribonucleic acid). They induce apoptotic death of cells after inhibiting protein translation. Ribosomes become functionally incompetent[...]texto impreso
Al Sazzad, Md. Abdullah ; Möuts, Anna ; Palacios Ortega, Juan ; Lin, Kai-Lan ; Nyholm, Thomas K. M. ; Slotte, J. Peter | Elsevier | 2019-03-19The mode of interactions between palmitoyl lysophosphatidylcholine (palmitoyl lyso-PC) or other lysophospholipids (lyso-PLs) and palmitoyl ceramide (PCer) or other ceramide analogs in dioleoylphosphatidylcholine (DOPC) bilayers has been examined[...]texto impreso
Rivera de Torre, Esperanza ; Palacios Ortega, Juan ; García Linares, Sara ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2017-12Sticholysins I and II (StnI and StnII), ?-pore forming toxins from the sea anemone Stichodactyla helianthus, are water-soluble toxic proteins which upon interaction with lipid membranes of specific composition bind to the bilayer, extend and ins[...]texto impreso
Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Linares, Sara | MDPI | 2019Animal venoms are complex mixtures of highly specialized toxic molecules. Cnidarians and arachnids produce pore-forming proteins (PFPs) directed against the plasma membrane of their target cells. Among PFPs from cnidarians, actinoporins stand ou[...]texto impreso
Palacios Ortega, Juan ; García Linares, Sara ; Astrand, Mia ; Abdullah Al Sazzad, Md. ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | ACS | 2016Sticholysin II (StnII) is a pore-forming toxin that uses sphingomyelin (SM) as the recognition molecule in targeting membranes.After StnII monomers bind to SM, several toxin monomers act in concert to oligomerize into a functional pore. The regu[...]texto impreso
Palacios Ortega, Juan ; García Linares, Sara ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | Elsevier | 2019-06-18Actinoporins are a group of soluble toxic proteins that bind to membranes containing sphingomyelin (SM) and oligomerize to form pores. Sticholysin II (StnII) is a member of the actinoporin family, produced by Stichodactyla helianthus. Cholestero[...]texto impreso
Rivera de Torre, Esperanza ; Palacios Ortega, Juan ; Garb, Jessica E. ; Slotte, J. Peter ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2020Actinoporins are a family of pore-forming toxins produced by sea anemones as part of their venomous cocktail. These proteins remain soluble and stably folded in aqueous solution, but when interacting with sphingomyelin-containing lipid membranes[...]texto impreso
García Linares, Sara ; Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Eslsevier | 2017Sea anemones produce venoms containing different toxic molecules. Among them, actinoporins are some of the best characterized ones. They constitute a family of toxic polypeptides that belong to the much larger group of pore-forming toxins. Actin[...]texto impreso
García Linares, Sara ; Palacios Ortega, Juan ; Yasuda, Tomokazu ; Astrand, Mia ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | Elsevier | 2016-03-11Sticholysin I and II (StnI and StnII) are pore-forming toxins that use sphingomyelin (SM) for membrane binding. We examined how hydrogen bonding among membrane SMs affected the StnI- and StnII-induced pore formation process, resulting in bilayer[...]
