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Martínez de Toda Cabeza, Irene ; Miguélez, Lara ; Vida, Carmen ; Carro, Eva ; Fuente del Rey, Mónica de la | IOS Press | 2019-09-03Oxidative stress plays an essential and early role in the pathophysiology of Alzheimer’s disease (AD). Alterations in the redox state in AD and in mild cognitive impairment (MCI) patients appear in the brain and at peripheral level. Given that i[...]texto impreso
The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-li[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Sanz San Miguel, Luis ; Fuente del Rey, Mónica de la | Hindawi | 2019-06-02According to the oxidative-inflammatory theory of aging, there is a link between the function, the oxidative-inflammatory stress state of immune cells, and longevity. However, it is unknown which immune cell parameters can predict lifespan and i[...]texto impreso
Martínez de Toda Cabeza, Irene ; Miguélez, Lara ; Siboni, León ; Vida, Carmen ; Fuente del Rey, Mónica de la | Springer | 2019-08-08Chronic stress situations lead to an impairment of immune response and higher oxidative and inflammatory stress, which are important underlying mechanisms of the ageing process. However, given that the physiological stress response depends on th[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Ortega, Eduardo ; Fuente del Rey, Mónica de la | Elsevier | 2016-11Under stressful conditions, the expression of the chaperone Hsp70 is induced, which acts as a cellular defense mechanism. The impairment in this induction has been related to aging, whereas an increased expression has been related to longevity. [...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; García-Salmones, Marta ; Alonso-Fernández, Patricia ; Fuente del Rey, Mónica de la | Oxford University Press | 2019-10-20Several parameters of immune function, oxidative, and inflammatory stresses have been proposed as markers of health and predictors of longevity and mortality. However, it is unknown if any of these parameters can be used as predictors of surviva[...]texto impreso
Martínez de Toda Cabeza, Irene ; Maté, Ianire ; Vida, Carmen ; Cruces, Julia ; Fuente del Rey, Mónica de la | Aging | 2016Chronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the bi[...]texto impreso
Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Garrido Tarrio, Antonio ; Caro, Eva ; Molina, José Antonio ; Fuente del Rey, Mónica de la | Frontiers Media | 2018-01Since aging is considered the most risk factor for sporadic Alzheimer’s Disease (AD), the age-related impairment of the immune system (immunosenescence), based on a chronic oxidative-inflammatory stress situation, could play a key role in the de[...]texto impreso
Vida, Carmen ; Carracedo Añón, Julia ; Sequera, Patricia de ; Bodega, Guillermo ; Pérez, Rafael ; Alique, Matilde ; Ramírez, Rafael | MDPI | 2020-04-15Oxidative stress is exacerbated in hemodialysis patients by several factors, including the uremic environment and the use of dialysis fluids (DFs). Since magnesium (Mg) plays a key role in modulating immune function and in reducing oxidative str[...]texto impreso
Vida, Carmen ; Kobayashi, Hikaru ; Garrido, Antonio ; Martínez de Toda, Irene ; Carro, Eva ; Molina, José ; Fuente del Rey, Mónica de la | MDPI | 2019-02-12In Parkinson’s Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of th[...]texto impreso
Carracedo, Julia ; Alique, Matilde ; Vida, Carmen ; Bodega, Guillermo ; Ceprián, Noemí ; Morales, Enrique ; Praga, Manuel ; Sequera, Patricia de ; Ramírez, Rafael | Frontiers Media | 2020-03-20Cardiovascular diseases (CVDs), especially those involving a systemic inflammatory process such as atherosclerosis, remain the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). CKD is a systemic condition af[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Garrido Tarrio, Antonio ; Fuente del Rey, Mónica de la | Oxford University Press | 2019-02-11Oxidative stress has been reported to increase with aging and although several agerelated changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and lifespan. Therefore, antioxidant (cata[...]texto impreso
Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Cruces, Julia ; Garrido Tarrio, Antonio ; González Sánchez, Mónica ; Fuente del Rey, Mónica de la | Elsevier | 2017The age-related changes in the immune functions (immunosenescence) may be mediated by an increase of oxidative stress and damage affecting leukocytes. Although the “oxidation-inflammation” theory of aging proposes that phagocytes are the main im[...]texto impreso
Díaz del Cerro, Estefanía ; Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Félix, Judith ; Fuente del Rey, Mónica de la | BMC | 2020-11-23Background: The immune system, as a homeostatic system, is an excellent marker of health and has also been proposed as an indicator of the rate of aging. The base of the age-related changes in the immune system, “immunosenescence”, is oxidative-[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Sanz San Miguel, Luis ; Fuente del Rey, Mónica de la | Elsevier | 2019-09The identification of predictive markers of life span would help to unravel the underlying mechanisms influencing ageing and longevity. For this aim, 30 variables including immune functions, inflammatory-oxidative stress state and behavioural ch[...]
