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The neocortex (commonly referred to as cerebral cortex) is the most complex and recently evolved structure in the mammalian brain. It contains hundreds of cell-types assembled into sophisticated neural circuits that –by integrating information f[...]texto impreso
Díaz Alonso, Javier ; Aguado, Tania ; Salas Quiroga, Adán de ; Ortega, Zaira ; Guzmán, Manuel ; Galve Roperh, Ismael | Oxford University Press | 2015-09The CB1 cannabinoid receptor regulates cortical progenitor proliferation during embryonic development, but the molecular mechanism of this action remains unknown. Here, we report that CB1-deficient mouse embryos show premature cell cycle exit, d[...]texto impreso
García Rincón, Daniel ; Díaz Alonso, Javier ; Paraíso Luna, Juan ; Otega, Zaira ; Aguareles, José ; Salas Quiroga, Adán de ; Jou, Cristina ; Prada, Inmaculada de ; Martínez Cerdeño, Verónica ; Aronica, Eleonora ; Guzmán, Manuel ; Pérez-Jiménez, María Ángeles ; Galve Roperh, Ismael | Frontiers Media | 2019-01Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly an[...]texto impreso
Salas Quiroga, Adán de ; García-Rincón, Daniel ; Gómez-Domínguez, Daniel ; Valero, Manuel ; Simón-Sánchez, Samuel ; Paraíso-Luna, Juan ; Aguareles, José ; Pujadas, Mitona ; Muguruza, Carolina ; Callado, Luis F. ; Lutz, Beat ; Guzmán, Manuel ; Menéndez de la Prida, Liset ; Galve-Roperh, Manuel | Springer Nature | 2020-01-26Prenatal exposure to ?9 -tetrahydrocannabinol (THC), the most prominent active constituent of cannabis, alters neurodevelopmental plasticity with a long-term functional impact on adult offspring. Specifically, THC affects the development of pyra[...]texto impreso
Díaz Alonso, Javier ; Salas Quiroga, Adán de ; Paraíso Luna, Juan ; García Rincón, Daniel ; Garcez, Patricia P. ; Parsons, Maddy ; Andradas Arias, Clara | Oxford University Press | 2017-11Neuronal migration is a fundamental process of brain development, and its disruption underlies devastating neurodevelopmental disorders. The transcriptional programs governing this process are relatively well characterized. However, how environm[...]texto impreso
Salas Quiroga, Adán de ; Díaz Alonso, Javier ; García-Rincón, Daniel ; Remmers, Floortje ; Vega, David ; Gómez Cañas, María ; Lutz, Beat ; Guzmán, Manuel ; Galve Roperh, Ismael | National Academy of Sciences | 2015-11The CB1 cannabinoid receptor, the main target of ?9 -tetrahydrocannabinol (THC), the most prominent psychoactive compound of marijuana, plays a crucial regulatory role in brain development as evidenced by the neurodevelopmental consequences of i[...]
