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Gil, Anabel ; Rodríguez Escudero, Isabel ; Stumpf, Miriam ; Molina Martín, María ; Jiménez Cid, Víctor ; Pulido, Rafael | 2015-04-15Spatial regulation of the tumor suppressor PTEN is exerted through alternative plasma membrane, cytoplasmic, and nuclear subcellular locations. The N-terminal region of PTEN is important for the control of PTEN subcellular localization and funct[...]texto impreso
Rodríguez Escudero, Isabel ; Fernández Acero, Teresa ; Cid, Víctor J. ; Molina, María | Nature Research | 2018-05-16The Akt protein kinase is the main transducer of phosphatidylinositol-3,4,5-trisphosphate (PtdIns3,4,5P) signaling in higher eukaryotes, controlling cell growth, motility, proliferation and survival. By co-expression of mammalian class I phospha[...]texto impreso
Jiménez Cid, Víctor ; Calvo de Pablo, Pilar ; Román González, Elvira ; Patiño Álvarez, Aurora Belén ; González Zorn, Bruno ; Gómez-Luz Centelles, María Luisa ; Molina Martín, María ; Martín Brieva, Humberto ; Escudero García-Calderón, José Antonio ; Pavón Vergés, Mónica ; Rodríguez Fernández, Carmina ; Díaz del Toro, Silvia ; Rodríguez Escudero, Isabel ; Vázquez Estévez, Covadonga ; Bezos Garrido, Javier ; Álvarez Sánchez, Julio ; Amaro Torres, Francisco ; Suárez Rodríguez, Mónica ; Gil Serna, Jéssica ; Fernández-Acero Bascones, Teresa ; Sanz Santamaría, Ana Belén ; González Rubio, Gema ; Jiménez Gutiérrez, Elena ; Coronas Serna, Julia María ; Valenti Sanguino, Marta ; del Val Oriza, Elba ; Sellers Moya, Ángela ; Prieto, Alicia ; Arias, Patricia ; Sastre Vergara, Lucía | Proyecto ApS UCM | 2020-09-30MicroMundo es un proyecto de Ciencia Ciudadana basado en aprendizaje activo, en el que estudiantes de ESO y Bachillerato, objeto del servicio, coordinados por equipos de estudiantes universitarios, objeto del aprendizaje, desarrollan un proyecto[...]texto impreso
Mingo, Janire ; Rodríguez Escudero, Isabel ; Luna, Sandra ; Fernández Acero, Teresa ; Amo, Laura ; Jonasson, Amy R ; Zori, Roberto T ; López, José I ; Molina, María ; Cid, Víctor J. ; Pulido, Rafael | Springer Nature | 2018-04-30The PTEN gene encodes a master regulator protein that exerts essential functions both in the cytoplasm and in the nucleus. PTEN is mutated in the germline of both patients with heterogeneous tumor syndromic diseases, categorized as PTEN hamartom[...]texto impreso
Rodríguez Escudero, María ; Cid, Víctor J. ; Molina, María ; Schulze Luehrmann, Jan ; Lührmann, Anja ; Rodríguez Escudero, Isabel | 2016-01-28Coxiella burnetii is a Gram-negative obligate parasitic bacterium that causes the disease Q-fever in humans. To establish its intracellular niche, it utilizes the Icm/Dot type IVB secretion system (T4BSS) to inject protein effectors into the hos[...]texto impreso
Fernández Acero, Teresa ; Rodríguez Escudero, Isabel ; Molina, María ; Cid, Víctor J. | Elsevier | 2015-08-07Phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] is essential for recognition of the plasma membrane inner leaf by protein complexes. We expressed mammalian class I phosphoinositide 3-kinase (PI3K) in Saccharomyces cerevisiae to eliminate[...]texto impreso
Fernández Acero, Teresa ; Rodríguez Escudero, Isabel ; Vicente, Francisca ; Monteiro, Maria Cândida ; Tormo, José R. ; Cantizani, Juan ; Molina, María ; Cid, Víctor J. | 2012-06-15The phosphatidylinositol 3-kinase (PI3K) pathway couples receptor-mediated signaling to essential cellular functions by generating the lipid second messenger phosphatidylinositol-3,4,5-trisphosphate. This pathway is implicated in multiple aspect[...]texto impreso
Rodríguez Escudero, Isabel ; Fernández Acero, Teresa ; Bravo, Ignacio ; Leslie, Nicholas R. ; Pulido, Rafael ; Molina, María ; Cid, Víctor J. | Elsevier | 2015-05-01The PTEN phosphoinositide 3-phosphatase is a tumor suppressor commonly targeted by pathologic missense mutations. Subject to multiple complex layers of regulation, its capital role in cancer relies on its counteracting function of class I phosph[...]
