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Granier, Sophie A ; Hidalgo, Laura ; San Millán, Álvaro ; Escudero, José Antonio ; Gutiérrez, Belén ; Brisabois, Anne ; González Zorn, Bruno | American Society for Microbiology | 2011-11The 16S rRNA methyltransferase ArmA is a worldwide emerging determinant that confers high-level resistance to most clinically relevant aminoglycosides. We report here the identification and characterization of a multidrug-resistant Salmonella en[...]texto impreso
Gutiérrez, Belén ; Escudero, José Antonio ; San Millán, Álvaro ; Hidalgo, Laura ; Carrilero Aguado, Laura ; Martínez Ovejero, Cristina ; Santos López, Alfonso ; Thomas López, Daniel ; González Zorn, Bruno | American Society for Microbiology | 2012-05Arm/Rmt methyltransferases have emerged recently in pathogenic bacteria as enzymes that confer high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA (like ArmA and RmtA to -E). In pro[...]texto impreso
Escudero, José Antonio ; San Millán, Álvaro ; Gutiérrez, Belén ; Hidalgo, Laura ; La Ragione, Roberto M ; AbuOun, Manal ; Galimand, Marc ; Ferrándiz, María José ; Domínguez Rodríguez, Lucas ; de la Campa, Adela G ; González Zorn, Bruno | American Society for Microbiology | 2011-12Streptococcus suis is an emerging zoonotic pathogen. With the lack of an effective vaccine, antibiotics remain the main tool to fight infections caused by this pathogen. We have previously observed a reserpine-sensitive fluoroquinolone (FQ) effl[...]texto impreso
San Millán, Álvaro ; Garcia Cobos, Silvia ; Escudero, José Antonio ; Hidalgo, Laura ; Gutiérrez, Belén ; Carrilero Aguado, Laura ; Campos, José ; González Zorn, Bruno | American Society for Microbiology | 2010-04Plasmid pB1000 is a mobilizable replicon bearing the bla(ROB-1) beta-lactamase gene that we have recently described in Haemophilus parasuis and Pasteurella multocida animal isolates. Here we report the presence of pB1000 and a derivative plasmid[...]texto impreso
Søndergaard, Annette ; San Millán, Álvaro ; Santos López, Alfonso ; Nielsen, Signe M ; González Zorn, Bruno ; Nørskov-Lauritsen, Niels | American Society for Microbiology | 2012-09TEM-1 is the dominant ?-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a [...]texto impreso
San Millán, Álvaro ; Escudero, José Antonio ; Gutiérrez, Belén ; Hidalgo, Laura ; Garcia, Nerea ; Llagostera, Montserrat ; Domínguez Rodríguez, Lucas ; González Zorn, Bruno | American Society for Microbiology | 2009-08In most gram-negative bacteria, acquired multiresistance is conferred by large plasmids compiling numerous antimicrobial resistance genes. Here, we show an evolutionary alternative strategy used by Pasteurella multocida to become resistant to mu[...]texto impreso
Escudero, José Antonio ; San Millán, Álvaro ; Montero Serra, Natalia ; Gutiérrez, Belén ; Martínez Ovejero, Cristina ; Carrilero Aguado, Laura ; González Zorn, Bruno | American Society for Microbiology | 2013-07Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here, we describe a[...]texto impreso
San Millán, Álvaro ; Santos López, Alfonso ; Ortega Huedo, Rafael ; Bernabé Balas, Cristina ; Kennedy, Sean P ; González Zorn, Bruno | American Society for Microbiology | 2015Plasmids play a key role in the horizontal spread of antibiotic resistance determinants among bacterial pathogens. When an antibiotic resistance plasmid arrives in a new bacterial host, it produces a fitness cost, causing a competitive disadvant[...]texto impreso
San Millán, Álvaro ; Depardieu, Florence ; Godreuil, Sylvain ; Courvalin, Patrice | American Society for Microbiology | 2009-05Three Enterococcus faecium strains isolated successively from the same patient, vancomycin-resistant strain BM4659, vancomycin-dependent strain BM4660, and vancomycin-revertant strain BM4661, were indistinguishable by pulsed-field gel electropho[...]
