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Gutiérrez, Belén ; Escudero, José Antonio ; San Millán, Álvaro ; Hidalgo, Laura ; Carrilero Aguado, Laura ; Martínez Ovejero, Cristina ; Santos López, Alfonso ; Thomas López, Daniel ; González Zorn, Bruno | American Society for Microbiology | 2012-05Arm/Rmt methyltransferases have emerged recently in pathogenic bacteria as enzymes that confer high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA (like ArmA and RmtA to -E). In pro[...]texto impreso
Los antibióticos han salvado millones de vidas desde que en la década de 1940 se introdujeran en la práctica clínica. Desafortunadamente debido a la rápida aparición de resistencias, su fácil diseminación y la dificultad de su eliminación una ve[...]texto impreso
Hidalgo, Laura ; Gutiérrez, Belén ; Martínez Ovejero, Cristina ; Carrilero Aguado, Laura ; Matrat, Stephanie ; Saba, Courage K S ; Santos López, Alfonso ; Thomas López, Daniel ; Hoefer, Andreas ; Suárez Rodríguez, Mónica ; Santurde Sánchez, Gloria ; Martín Espada, Carmen ; González Zorn, Bruno | American Society for Microbiology | 2013-09Seven Klebsiella pneumoniae isolates from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by multilocus sequence typing (MLST) as[...]texto impreso
Søndergaard, Annette ; San Millán, Álvaro ; Santos López, Alfonso ; Nielsen, Signe M ; González Zorn, Bruno ; Nørskov-Lauritsen, Niels | American Society for Microbiology | 2012-09TEM-1 is the dominant ?-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a [...]texto impreso
Moleres, Javier ; Santos López, Alfonso ; Lázaro, Isidro ; Labairu, Javier ; Prat, Cristina ; Ardanuy, Carmen ; González Zorn, Bruno ; Aragón, Virginia ; Garmendia, Junkal | American Society for Microbiology | 2015-05-01Haemophilus parasuis, the causative agent of Glässer's disease, is one of the early colonizers of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with disease are fibrinous polyserositis and bronchopneumonia. [...]texto impreso
Cannatelli, Antonio ; Santos López, Alfonso ; Giani, Tommaso ; González Zorn, Bruno ; Rossolini, Gian Maria | American Society for Microbiology | 2015-05The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Kleb[...]texto impreso
San Millán, Álvaro ; Santos López, Alfonso ; Ortega Huedo, Rafael ; Bernabé Balas, Cristina ; Kennedy, Sean P ; González Zorn, Bruno | American Society for Microbiology | 2015Plasmids play a key role in the horizontal spread of antibiotic resistance determinants among bacterial pathogens. When an antibiotic resistance plasmid arrives in a new bacterial host, it produces a fitness cost, causing a competitive disadvant[...]
