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Cejalvo, Teresa ; Muñoz, Juan J. ; Tobajas, Esther ; Alfaro Sánchez, David ; García Ceca Hernández, Javier ; Zapata González, Agustín | Springer Link | 2015-05Our understanding about medullary compartment, its niches composition and formation is still limited. Previous studies using EphB2 and/or EphB3 knockout mice showed an abnormal thymic development that affects mainly to the epithelial component, [...]texto impreso
García Ceca Hernández, Javier ; Alfaro Sánchez, David ; Montero Herradón, Sara ; Tobajas, Esther ; Muñoz, Juan José ; Zapata González, Agustín | Frontiers Media | 2015-06-26Numerous studies emphasize the relevance of thymocyte–thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and th[...]texto impreso
Muñoz, Juan José ; Tobajas, Esther ; Juara, Sonia ; Montero Herradón, Sara ; Zapata González, Agustín Gregorio | Springer | 2019-09-24The mechanisms that determine the commitment of thymic epithelial precursors to the two major thymic epithelial cell lineages, cTECs and mTECs, remain unknown. Here we show that FoxN1 nu mutation, which abolishes thymic epithelium differentiatio[...]
