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Román, Domingo ; Pizarro, I. ; Rivera, L. ; Cámara Rica, Carmen ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros ; Solar, Carlos | SAGE | 2010Among non-cancer effects of arsenic, cardiovascular diseases have been well documented; however, few are known about the arsenic fate in cardiovascular tissues. We studied the analytic bioinorganic arsenic behaviour in cardiovascular tissues fro[...]texto impreso
Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Cañas, Benito ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2010Pt-containing drugs are nowadays essential components in cancer chemotherapy. However, drug resistance and side effects limit the efficiency of the treatments. In order to improve the response to Pt-based drugs, different administration strategi[...]texto impreso
Pizarro, I. ; Roman Silva, D.A. ; Gómez Gómez, M.Milagros ; Cámara Rica, Carmen ; Palacios Corvillo, M.Antonia | Chilean Chemical Society | 2013The intracellular As-protein binding in cytosol and methanol–water extract of the auricle and saphene tissues of As impacted people was evaluated by bidimensional size exclusion FPLC-UV-ICP-MS. The fractionation of cytosol using Superdex, Phenom[...]texto impreso
Pizarro, Isabel ; Gómez Gómez, M.Milagros ; Román, Domingo ; Palacios Corvillo, M.Antonia | OMICS International | 2016Studies on the bioavailability of As, Cr, Cu, Pb, Mn and Cd of impacted soils; the As bioaccesibility in the edible parts of carrots, beets and quinoa growing in these polluted soils thought “in vitro” gastrointestinal process; the As speciation[...]texto impreso
Pizarro, Isabel ; Artiaga, Gema ; Gómez Gómez, M.Milagros ; Palacios Corvillo, M.Antonia | Asian Journal of Science and Technology | 2018Arsenic in the Antofagasta Region of Chile is worldwide recognized as highly As contaminated area. Due to its abundance, mainly as As (V) and As (III), certain microorganisms such as several types of bacteria have evolved and developed the neces[...]texto impreso
Pizarro, I ; Roman Silva, D.A. ; Solar, Carlos ; Cámara Rica, Carmen ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | Sociedad Chilena de Cardiología y Cirugía Cardiovascular | 2013Introducción: Los efectos de la intoxicación con Arsénico (As) como enfermedades cardiovasculares (CV), pigmentaciones y oclusiones arteriales coronarias están asociados con la ingestión de As inorgánico a través del agua de bebida y a exposicio[...]texto impreso
Moreno Gordaliza, Estefanía ; Cañas Montalvo, Benito ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | Royal Society of Chemistry | 2010The characterization of the interaction of platinum drugs with proteins has been previously performed using bottom-up proteomics approaches (enzymatic digestion followed by MS analysis). Nevertheless, the study of the stability of the Pt–protein[...]texto impreso
SEC-ICP-MS and ESI-MS as tools to study the interaction between cisplatin and cytosolic biomolecules
Esteban Fernández, Diego ; Cañas, Benito ; Pizarro, I. ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2007Most of cisplatin’s citotoxic properties are due to the interaction of the drug with DNA. However, other biological molecules present in the cell cytosol, such as MT (metallothionein) and GSH (glutathione), are potential targets for cisplatin an[...]texto impreso
Esteban Fernández, Diego ; Gómez Gómez, M.Milagros ; Cañas, Benito ; Verdaguer, J.M. ; Ramírez, R. ; Palacios Corvillo, M.Antonia | Elsevier | 2007Chemical compounds containing platinum have been employed since 1978 as drugs to beat certain type of tumours. Nevertheless, besides of their exceptional antitumoral properties, these drugs also have important deleterious side effects, such as, [...]texto impreso
Pizarro, I ; Roman Silva, D.A. ; Solar, Carlos ; Gómez Gómez, M.Milagros ; Cámara Rica, Carmen ; Palacios Corvillo, M.Antonia | Chilean Chemical Society | 2012The concentration levels of As in the Chilean II Region of Antofagasta produces non cancer health outcomes such as cardiovascular diseases and in last term heart attack. On this study, the determination of total As content and main inorganic and[...]
