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Lacadena, Javier ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Herrero Galán, Elías ; Alegre Cebollada, Jorge ; García Ortega, Lucía ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007RNase T1 is the best known representative of a large family of ribonucleolytic proteins secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among them by their cytotoxic character. They exert their toxic action by[...]texto impreso
Olombrada, Miriam ; Lázaro Gorines, Rodrigo ; López Rodríguez, Juan C. ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Maestro López, Moisés ; Lacadena, Javier ; Gavilanes, José G. ; García Ortega, Lucía | MDPI | 2017Fungi establish a complex network of biological interactions with other organisms in nature. In many cases, these involve the production of toxins for survival or colonization purposes. Among these toxins, ribotoxins stand out as promising candi[...]texto impreso
Herrero Galán, Elías ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Gavilanes, José G. | Caister Academic Press | 2009Ribotoxins are a family of fungal extracellular ribonucleases which inactivate ribosomes by specifically cleaving a single phosphodiester bond located at the universally conserved sarcin/ricin loop of the large rRNA. The subsequent inhibition of[...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2015-11Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2016Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]texto impreso
Maestro-López, Moisés ; Olombrada, Miriam ; García Ortega, Lucía ; Serrano González, Daniel ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2017-03-07Fungal ribotoxins are highly specific extracellular RNases which cleave a single phosphodiester bond at the ribosomal sarcin-ricin loop, inhibiting protein biosynthesis by interfering with elongation factors. Most ribotoxins show high degree of [...]texto impreso
Tomé-Amat, Jaime ; Herrero-Galán, Elías ; Oñaderra, Mercedes ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-06Immunotoxins are chimeric proteins composed of an antibody domain that specifically directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent years, immunotoxins have been widely studied and the number of [...]texto impreso
Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007-12Actinoporins are a family of 20-kDa, basic proteins isolated from sea anemones, whose activity is inhibited by preincubation with sphingomyelin. They are produced in monomeric soluble form but, when binding to the plasma membrane, they oligomeri[...]texto impreso
Carreras Sangrà, Nelson ; Álvarez García, Elisa ; Herrero Galán, Elías ; Tomé, Jaime ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Bentham Science Publishers Ltd. | 2008Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin–ricin loop. This cleavage of a single phosphodiester bond inactiv[...]
