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To consider the lung as a target for drug delivery and to optimise strategies directed at the pulmonary route, it is essential to consider the role of pulmonary surfactant, a thin lipid–protein film lining the respiratory surface of mammalian lu[...]texto impreso
Mato, Aranzazu ; Tarazona Lizcano, Natalia Andrea ; Hidalgo Román, Alberto ; Cruz Rodríguez, Antonio ; Jiménez, Mercedes ; Pérez-Gil, Jesús ; Prieto Jiménez, María Auxiliadora | American Chemical Society | 2019-01Phasins, the major proteins coating polyhydroxyalkanoate (PHA) granules, have been proposed as suitable biosurfactants for multiple applications because of their amphiphilic nature. In this work, we analyzed the interfacial activity of the amphi[...]texto impreso
Hidalgo Román, Alberto ; García-Mouton, Cristina ; Autilio, Chiara ; Carravilla, Pablo ; Orellana Moraleda, Guillermo ; Islam, Mohammad N. ; Bhattacharya, Jahar ; Bhattacharya, Sunita ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Elsevier | 2020-11-24This work explores the potential for strategizing pulmonary surfactant (PS) for drug delivery over the respiratory air-liquid interface: the interfacial delivery. The efficacy of PS- and interface-assisted drug vehiculization was determined both[...]texto impreso
Pulmonary surfactant is a membrane-based lipid-protein system essential for the process of breathing, which coats and stabilizes the whole respiratory surface and possesses exceptional biophysical properties. It constitutes the first barrier aga[...]texto impreso
Uno de los retos de los últimos años ha sido diseñar y desarrollar nuevas estrategias para el transporte de fármacos, particularmente estrategias menos invasivas y dirigidas a dianas específicas del organismo. En este sentido, los nuevos avances[...]texto impreso
García-Mouton, Cristina ; Hidalgo Román, Alberto ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Elsevier | 2019-09-24
