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To consider the lung as a target for drug delivery and to optimise strategies directed at the pulmonary route, it is essential to consider the role of pulmonary surfactant, a thin lipid–protein film lining the respiratory surface of mammalian lu[...]texto impreso
Oeo-Santos, Carmen ; López Rodríguez, Juan C. ; García-Mouton, Cristina ; San Segundo-Acosta, Pablo ; Jurado, Aurora ; Moreno-Aguilar, Carmen ; García-Álvarez, Begoña ; Pérez Gil, Jesús ; Villalba, Mayte ; Barderas Manchado, Rodrigo ; Cruz Rodríguez, Antonio | Elsevier | 2020-03-04Ole e 7 allergen from Olea europaea pollen possesses a major clinical relevance because it produces severe symptoms, such as anaphylaxis, in allergic patients exposed to high olive pollen counts. Ole e 7 is a non-specific lipid transfer protein [...]texto impreso
Carravilla, Pablo ; Cruz Rodríguez, Antonio ; Martín-Ugarte, Itziar ; Oar-Arteta, Itziar R. ; Torralba, Johanna ; Apellaniz, Beatriz ; Pérez Gil, Jesús ; Requejo Isidro, José ; Huarte, Nerea ; Nieva, José L. | BIOPHYSICAL SOCIETY | 2017-09-19Membrane fusion induced by the envelope glycoprotein enables the intracellular replication of HIV-1; hence, this process constitutes a major target for antiretroviral compounds. It has been proposed that peptides having propensity to interact wi[...]texto impreso
Hidalgo, Alberto ; Salomone, Fabrizio ; Fresno, Nieves ; Orellana Moraleda, Guillermo ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | American Chemical Society | 2017Pulmonary surfactant is a crucial system to stabilize the respiratory air-liquid interface. Furthermore, pulmonary surfactant has been proposed as an effective method for targeting drugs to the lungs. However, few studies have examined in detail[...]texto impreso
Huarte, Nerea ; Carravilla, Pablo ; Cruz Rodríguez, Antonio ; Lorizate, Maier ; Nieto-Garay, Jon A. ; Kräusslich, Hans-Georg ; Pérez Gil, Jesús ; Requejo Isidro, José ; Nieva, José L. | Nature Publishing Group | 2016The chemical composition of the human immunodeficiency virus type 1 (HIV-1) membrane is critical for fusion and entry into target cells, suggesting that preservation of a functional lipid bilayer organization may be required for efficient infect[...]texto impreso
Mato, Aranzazu ; Tarazona Lizcano, Natalia Andrea ; Hidalgo Román, Alberto ; Cruz Rodríguez, Antonio ; Jiménez, Mercedes ; Pérez-Gil, Jesús ; Prieto Jiménez, María Auxiliadora | American Chemical Society | 2019-01Phasins, the major proteins coating polyhydroxyalkanoate (PHA) granules, have been proposed as suitable biosurfactants for multiple applications because of their amphiphilic nature. In this work, we analyzed the interfacial activity of the amphi[...]texto impreso
Olmeda Lozano, Bárbara ; García Álvarez, Begoña ; Gómez, Manuel J. ; Martínez Calle, Marta ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Federation of American Societies for Experimental Biology | 2017Surfactant protein B (SP-B), from the saposin-like family of proteins, is essential to facilitate the formation and proper performance of surface active films at the air-liquid interface of mammalian lungs, and lack of or deficiency in this prot[...]texto impreso
Cerrada, Alejandro ; Haller, Thomas ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Cross Mark | 2015-12Pulmonary surfactant (PS) is an essential complex of lipids and specific proteins synthesized in alveolar type II pneumocytes, where it is assembled and stored intracellularly as multilayered organelles known as lamellar bodies (LBs). Once secre[...]texto impreso
Hidalgo Román, Alberto ; García-Mouton, Cristina ; Autilio, Chiara ; Carravilla, Pablo ; Orellana Moraleda, Guillermo ; Islam, Mohammad N. ; Bhattacharya, Jahar ; Bhattacharya, Sunita ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Elsevier | 2020-11-24This work explores the potential for strategizing pulmonary surfactant (PS) for drug delivery over the respiratory air-liquid interface: the interfacial delivery. The efficacy of PS- and interface-assisted drug vehiculization was determined both[...]texto impreso
Pulmonary surfactant is a membrane-based lipid-protein system essential for the process of breathing, which coats and stabilizes the whole respiratory surface and possesses exceptional biophysical properties. It constitutes the first barrier aga[...]texto impreso
López-Rodríguez, Juan C. ; Barderas Manchado, Rodrigo ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Villalba, Mayte ; Batanero Cremades, Eva ; Cruz Rodríguez, Antonio | American Chemical Society | 2016-10-25Aeroallergens are airborne substances?mainly proteins?capable of triggering Th2-immune responses in respiratory allergies. They enter into the body through the upper airways, reaching the mucosa afterward. Mucosae lining at the luminal side cons[...]texto impreso
García-Mouton, Cristina ; Hidalgo Román, Alberto ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Elsevier | 2019-09-24
