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Alegre Cebollada, Jorge ; Cunietti, Michela ; Herrero Galán, Elías ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2008-08The mechanisms by which pore-forming toxins are able to insert into lipid membranes are a subject of the highest interest in the field of lipid–protein interaction. Eight mutants affecting different regions of sticholysin II, a member of the por[...]texto impreso
Lacadena, Javier ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Herrero Galán, Elías ; Alegre Cebollada, Jorge ; García Ortega, Lucía ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007RNase T1 is the best known representative of a large family of ribonucleolytic proteins secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among them by their cytotoxic character. They exert their toxic action by[...]texto impreso
Herrero Galán, Elías ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Gavilanes, José G. | Caister Academic Press | 2009Ribotoxins are a family of fungal extracellular ribonucleases which inactivate ribosomes by specifically cleaving a single phosphodiester bond located at the universally conserved sarcin/ricin loop of the large rRNA. The subsequent inhibition of[...]texto impreso
Alegre Cebollada, Jorge ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Goormaghtigh, Erik | 2007-11The structure of the actinoporin sticholysin II (StnII) in the pore state was investigated by Fourier transform infrared spectroscopy in the attenuated total reflection configuration. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/cholesterol [...]texto impreso
Álvarez García, Elisa ; Alegre Cebollada, Jorge ; Batanero Cremades, Eva ; Monedero, Vicente ; Pérez Martínez, Gaspar ; García Fernández, Rosa ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007-06-25Fungal ribotoxins are a family of extracellular ribonucleases which inhibit protein biosynthesis by inactivating the ribosomes. This inactivation results in the induction of cell death by apoptosis. Ribotoxins show antitumoral properties based o[...]texto impreso
Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007-12Actinoporins are a family of 20-kDa, basic proteins isolated from sea anemones, whose activity is inhibited by preincubation with sphingomyelin. They are produced in monomeric soluble form but, when binding to the plasma membrane, they oligomeri[...]texto impreso
Rivera de Torre, Esperanza ; García Linares, Sara ; Alegre Cebollada, Jorge ; Lacadena, Javier ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | American Society for Biochemistry and Molecular Biology | 2016-04-27Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are pore forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multigene[...]texto impreso
Rivera de la Torre, Esperanza ; García Linares, Sara ; Alegre Cebollada, Jorge ; Lacadena, Javier ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | ASBMB American Society for Biochemistry and Molecular Biology | 2016Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are the pore-forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multi[...]texto impreso
García Ortega, Lucía ; Alegre Cebollada, Jorge ; García Linares, Sara ; Bruix, Marta ; Martínez del Pozo, Álvaro ; Gavilanes, José G. | Elsevier | 2011-09Actinoporins constitute a group of small and basic ?-pore forming toxins produced by sea anemones. They display high sequence identity and appear as multigene families. They show a singular behaviour at the water-membrane interface: In aqueous s[...]texto impreso
Carreras Sangrà, Nelson ; Álvarez García, Elisa ; Herrero Galán, Elías ; Tomé, Jaime ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Bentham Science Publishers Ltd. | 2008Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin–ricin loop. This cleavage of a single phosphodiester bond inactiv[...]
